Synthesis, spectroscopic, X-ray crystal structure, biological and DNA interaction studies of organotin(IV) complexes of 2-(4-ethoxybenzylidene) butanoic acid

被引：17
|
作者：
Tariq, Muhammad [1 ]
Muhammad, Niaz [2 ]
Ali, Saqib [1 ]
Shirazi, Jafir Hussain [3 ]
Tahir, Muhammad Nawaz [4 ]
Khalid, Nasir [5 ]
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan
[2] Abdul Wali Khan Univ, Dept Chem, Mardan, Pakistan
[3] Quaid I Azam Univ, Dept Microbiol, Islamabad 45320, Pakistan
[4] Univ Sargodha, Dept Phys, Sargodha, Pakistan
[5] Pakistan Inst Nucl Sci & Technol, Div Chem, Islamabad, Pakistan
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2014年 / 122卷
关键词：
Distannoxane; Antimicrobial activity; Antitumor activity; Cytotoxic activity; VITRO ANTITUMOR-ACTIVITY; SN-119; NMR-SPECTRA; CALF THYMUS DNA; C-13; NMR; DERIVATIVES; SCREENINGS; TRIORGANOTIN(IV); DIORGANOTIN(IV); 4-COORDINATE; BUTYLTIN;
D O I：
10.1016/j.saa.2013.11.065
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Six organotin(IV) carboxylates of the type R2SnL2 [R = CH3 (1), n-C4H9 (2), n-C8H17 (3)] and R3SnL [R = CH3 (4), n-C4H9 (5), C6H5 (6), where L = 2-(4-ethoxybenzylidene) butanoic acid, have been synthesized and characterized by elemental analysis, FT-IR and NMR (H-1, C-13). The complex (1) was also analyzed by single crystal X-ray analysis. The complexes were screened for antimicrobial, cytotoxic and anti-tumor activities. The results showed significant activity in each area of the activity with few exceptions. DNA interactions studies of ligand HL and representative complex 2 were investigated by UV-Visible absorption spectroscopy and viscosity measurements. The results showed that both ligand HL and complex 2 interact with SS-DNA via intercalation as well as minor groove binding. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：356 / 364
页数：9
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