Polycyclic N-Heterocyclic Compounds. Part 82: Synthesis and Evaluation of Anti-Platelet Aggregation Activity of 2,4-Disubstituted 5,6-Dihydro[1]benzothiepino[5,4-d]pyrimidine and Related Compounds

被引：0

作者：

Okuda, Kensuke ^{[1
]}

Hirota, Takashi ^{[2
]}

Sasaki, Kenji ^{[2
]}

机构：

[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, Japan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 04期

关键词：

VIVO ANTITHROMBOTIC EVALUATION; 3D QSAR ANALYSIS; DISCOVERY; DESIGN; AGENTS;

D O I：

10.1002/jhet.1741

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have synthesized a large number of tricyclic 2-substituted 4-alkylamino-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidines as part of our research to develop new effective anti-platelet drugs. A variety of alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising anti-platelet candidates with potencies superior to aspirin.

引用

页码：911 / 920

页数：10

共 35 条

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