Polycyclic N-Heterocyclic Compounds. Part 82: Synthesis and Evaluation of Anti-Platelet Aggregation Activity of 2,4-Disubstituted 5,6-Dihydro[1]benzothiepino[5,4-d]pyrimidine and Related Compounds

被引:0
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作者
Okuda, Kensuke [1 ]
Hirota, Takashi [2 ]
Sasaki, Kenji [2 ]
机构
[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
[2] Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, Japan
关键词
VIVO ANTITHROMBOTIC EVALUATION; 3D QSAR ANALYSIS; DISCOVERY; DESIGN; AGENTS;
D O I
10.1002/jhet.1741
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
We have synthesized a large number of tricyclic 2-substituted 4-alkylamino-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidines as part of our research to develop new effective anti-platelet drugs. A variety of alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising anti-platelet candidates with potencies superior to aspirin.
引用
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页码:911 / 920
页数:10
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