Ovarian control of pituitary sensitivity of luteinizing hormone secretion to gonadotropin-releasing hormone in women with the polycystic ovary syndrome

被引:9
|
作者
Dafopoulos, Konstantinos [1 ]
Venetis, Christos [1 ]
Pournaras, Spyros [2 ]
Kallitsaris, Athanasios [1 ]
Messinis, Ioannis E. [1 ]
机构
[1] Univ Thessalia, Sch Med, Dept Obstet & Gynecol, Larisa 41110, Greece
[2] Univ Thessalia, Sch Med, Dept Microbiol, Larisa 41110, Greece
关键词
FOLLICLE-STIMULATING-HORMONE; SURGE-ATTENUATING FACTOR; ANTERIOR-PITUITARY; INHIBIN; GNRH; FSH; LH;
D O I
10.1016/j.fertnstert.2009.04.033
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
This study investigated the ovarian control of LH responsiveness to GnRH in anovulatory women with the polycystic ovary syndrome (PCOS). It is suggested that the enhanced pituitary sensitivity of LH secretion to GnRH in anovulatory women with PCOS is not due to a reduced production but rather to a defect in the interaction of ovarian factors on the hypothalamic-pituitary system. (Fertil Steril (R) 2009;92:1378-80. (C)2009 by American Society for Reproductive Medicine.)
引用
收藏
页码:1378 / 1380
页数:3
相关论文
共 50 条
  • [31] Use of pulsatile gonadotropin-releasing hormone to induce monofolliculogenesis in polycystic ovary syndrome patients
    Filicori, M
    Pocognoli, P
    Cognigni, GE
    Casadio, P
    Cantelli, B
    Gessa, G
    Tabarelli, C
    Spettoli, D
    Ciampaglia, W
    Taraborelli, S
    Ferlini, F
    Arnone, R
    Pecorari, R
    Parmegiani, L
    OVULATION INDUCTION: UPDATE 98, 1998, : 55 - 60
  • [32] Polycystic ovary syndrome: Evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone
    Pastor, CL
    Griffin-Korf, ML
    Aloi, JA
    Evans, WS
    Marshall, JC
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (02): : 582 - 590
  • [33] Altered kinetics of pituitary response to gonadotropin-releasing hormone in women with variant luteinizing hormone: correlation with ovulatory disorders
    Takahashi, K
    Karino, K
    Kanasakia, H
    Miyazakia, K
    HORMONE RESEARCH, 2004, 61 (01) : 27 - 32
  • [34] PITUITARY-RESPONSIVENESS TO GONADOTROPIN-RELEASING-HORMONE AGONIST STIMULATION - A DOSE-RESPONSE COMPARISON OF LUTEINIZING-HORMONE FOLLICLE-STIMULATING-HORMONE SECRETION IN WOMEN WITH POLYCYSTIC-OVARY-SYNDROME AND NORMAL WOMEN
    CHEUNG, AP
    CHANG, RJ
    HUMAN REPRODUCTION, 1995, 10 (05) : 1054 - 1059
  • [35] Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in women
    Nicholls, J
    Lasley, BL
    Nakajima, ST
    Setchell, KDR
    Schneeman, BO
    JOURNAL OF NUTRITION, 2002, 132 (04): : 708 - 714
  • [36] Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice
    Grattan, David R.
    Jasoni, Christine L.
    Liu, Xinhuai
    Anderson, Greg M.
    Herbison, Allan E.
    ENDOCRINOLOGY, 2007, 148 (09) : 4344 - 4351
  • [37] STAUROSPORINE ENHANCES GONADOTROPIN-RELEASING HORMONE-STIMULATED LUTEINIZING-HORMONE SECRETION
    VANDERMERWE, PA
    MILLAR, RP
    WAKEFIELD, IK
    MACRAE, MB
    DAVIDSON, JS
    FEBS LETTERS, 1990, 267 (01) : 111 - 113
  • [38] Effects of gonadotropin-releasing hormone agonist and antagonist on ovarian activity in a mouse model for polycystic ovary
    Singh, Padmasana
    Srivastava, Raj Kamal
    Krishna, Amitabh
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2016, 163 : 35 - 44
  • [39] Treatment of hirsutism by Gonadotropin-releasing hormone agonist (GnRH-A), Finasteride and Flutamide in women with Polycystic Ovary Syndrome
    Falsetti, L
    Rosina, B
    Martini, P
    INFERTILITY AND ASSISTED REPRODUCTIVE TECHNOLOGY: FROM RESEARCH TO THERAPY, 1997, : 433 - 438
  • [40] PITUITARY AND OVARIAN RESPONSES TO LUTEINIZING-HORMONE RELEASING HORMONE IN A RAT WITH POLYCYSTIC OVARIES
    HEMMINGS, R
    FAROOKHI, R
    BRAWER, JR
    BIOLOGY OF REPRODUCTION, 1983, 29 (01) : 239 - 248