High prevalence of HBV genotype D in Syria and the clinical characteristics of hepatitis B e antigen-negative chronic hepatitis B

被引：14

作者：

Antaki, N. ^{[1
]}

Haffar, S. ^{[2
]}

Deeb, S. Ali ^{[3
]}

Assaad, F. ^{[4
]}

Abou Harb, R. ^{[2
]}

Zeibane, N. ^{[5
]}

Nasserelddine, M. ^{[6
]}

Ibrahim, N. ^{[7
]}

Alhaj, N. ^{[2
]}

Jabbour, E. ^{[8
]}

Aaraj, R. ^{[9
]}

Antaki, F. ^{[10
]}

Kebbewar, K. ^{[11
]}

机构：

[1] St Louis Hosp, Dept Gastroenterol & Hepatol, Aleppo, Syria

[2] Mouassat Hosp, Dept Gastroenterol, Damascus, Syria

[3] Damascus Hosp, Dept Gastroenterol, Damascus, Syria

[4] Squelbiye Natl Hosp, Dept Gastroenterol, Squelbiye, Syria

[5] Med Ctr Hosp, Dept Gastroenterol, Hama, Syria

[6] Sweida Natl Hosp, Dept Gastroenterol, Sweida, Syria

[7] Omaya Hosp, Dept Gastroenterol, Damascus, Syria

[8] Tabiyate Hosp, Dept Gastroenterol, Latakia, Syria

[9] Homs Natl Hosp, Dept Gastroenterol, Homs, Syria

[10] Wayne State Univ, Dept Gastroenterol, John D Dingell VA Med Ctr, Detroit, MI USA

[11] St Louis Hosp, Dept Lab Med, Aleppo, Syria

来源：

EPIDEMIOLOGY AND INFECTION | 2010年 / 138卷 / 01期

关键词：

Genotype D; genotype distribution; hepatitis B; HBeAg negative; Syria; VIRUS GENOTYPES; NATURAL-HISTORY; LAMIVUDINE; INFECTION; FREQUENCY;

D O I：

10.1017/S0950268809990288

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Hepatitis B virus (HBV) genotype D and hepatitis B e antigen (HBeAg) negative chronic hepatitis are the most prevalent in Mediterranean countries. No data have ever been published oil their prevalence in Syria, a country of intermediate endemicity for HBV. The aims of the current study were to determine the HBV genotype distribution in Syria, the prevalence of HBeAg-positive and HBeAg-negative chronic hepatitis and to analyse the clinical characteristics of each group. A total of 220 patients were included. Ninety-seven percent of the patients were of genotype D, and 72% were HBeAg negative. The HBeAg-negative patients were older, had a lower viral load, had more cirrhosis and the mode of contamination was known less than for HBeAg-positive patients. These findings have major implications in understanding the natural history of the infection and are of great relevance in the choice of therapy.

引用

页码：40 / 44

页数：5

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