The prognostic significance of whole-body and spleen MTV (metabolic tumor volume) scanning for patients with diffuse large B cell lymphoma

被引:7
|
作者
Yamanaka, Shintaro [1 ]
Miyagawa, Masao [2 ]
Sugawara, Yoshifumi [3 ]
Hasebe, Shinji [4 ]
Fujii, Tomomi [4 ,5 ]
Takeuchi, Kazuto [4 ]
Tanaka, Keiko [6 ,7 ]
Yakushijin, Yoshihiro [4 ,5 ]
机构
[1] Ehime Univ, Sch Med, Toon, Ehime, Japan
[2] Ehime Univ, Grad Sch Med, Dept Radiol, Toon, Ehime, Japan
[3] Natl Hosp Org Shikoku Canc Ctr, Dept Diagnost Radiol, Matsuyama, Ehime, Japan
[4] Ehime Univ Hosp, Ctr Canc, Toon, Ehime, Japan
[5] Ehime Univ, Grad Sch Med, Dept Clin Oncol, Toon, Ehime 7910295, Japan
[6] Ehime Univ, Grad Sch Med, Dept Epidemiol & Prevent Med, Toon, Ehime, Japan
[7] Ehime Univ Hosp, Translat Res Ctr, Res Promot Unit, Toon, Ehime, Japan
关键词
SUV; MTV; 18F-FDG-PET; Diffuse large B cell lymphoma; FDG-PET/CT; FOLLICULAR LYMPHOMA; RESPONSE ASSESSMENT; POOLED ANALYSIS; PREDICTOR; THERAPY; INDEX;
D O I
10.1007/s10147-020-01807-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Positron Emission Tomography-Computed Tomography (PET-CT) has been changing diagnostic and therapeutic strategies for patients with cancers, and several PET-CT-related prognostic factors have been reported. We have focused on metabolic tumor volumes (MTVs) over the whole body and in specific organs using 18F-PET-CT imaging, and have compared clinical data to know the prognosis of patients with diffuse large B cell lymphoma (DLBCL). Patients and methods From January 2006 to December 2016, patients who were newly diagnosed for de novo DLBCL and who received 18F-FDG PET-CT scans for disease staging at Ehime University Hospital were reviewed. Results A total of forty out of 108 patients with DLBCL were analyzed. The median and the average follow-up were 3.9 years and 3.6 years. Both MTV50 and MTV60 whole-body searching indicated effective prognostic values for patients with DLBCL statistically (P = 0.027). However, analysis of MTVs in the spleen and in bone marrow did not provide any prognostic value. Receiver operating characteristic (ROC) analysis indicated that the cutoff level 25.8 in MTV60 is the most effective prognostic value (P = 0.022) which predicts patient survival after treatment with R-CHOP chemotherapy. Conclusion MTV60 using whole-body scanning appears to be an effective indicator in DLBCL and indicates the patient prognosis.
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收藏
页码:225 / 232
页数:8
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