New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression

被引：26

作者：

Floudas, Achilleas ^{[1
,2
]}

Amu, Sylvie ^{[3
]}

Fallon, Padraic G. ^{[1
,2
]}

机构：

[1] Trinity Coll Dublin, Sch Med, Trinity Biomed Sci Inst, Dublin, Ireland

[2] Our Ladys Childrens Hosp, Natl Childrens Res Ctr, Dublin, Ireland

[3] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2016年 / 36卷

基金：

爱尔兰科学基金会;

关键词：

B cells; regulatory B cells; inflammation; IL-10; ANTI-CD20; MONOCLONAL-ANTIBODY; B10; CELLS; T-CELLS; PROTECTS MICE; AUTOIMMUNE; DEPLETION; DISEASE; INTERLEUKIN-10; EXPRESSION; INDUCTION;

D O I：

10.1007/s10875-016-0263-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory B (Breg) cells are important regulators of immune responses and in recent years our understanding of their phenotypical and functional characteristics has improved considerably. Initially all suppressive capabilities of Breg cells were attributed to the actions of the anti-inflammatory cytokine interleukin (IL)-10 secreted by Breg cells. Recent studies however, highlight additional and novel mechanisms that influence both the expansion of Breg cells and their capacity to suppress immunity. Here we provide an overview of the complexity of Breg cell populations and address the newly discovered IL-10 independent mechanisms of Breg cell expansion and immune-suppression.

引用

页码：S25 / S33

页数：9

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