IS -94INS/DELATTG POLYMORPHISM IN THE NUCLEAR FACTOR KAPPA-B1 GENE (NFKB1) ASSOCIATED WITH NECROTIZING ENTEROCOLITIS?
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作者:
Ferdinando, Danielle Lopes Teixeira
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Fac Med Sao Jose do Rio Preto, Pediat & Pediat Surg, Sao Jose Do Rio Preto, SP, BrazilFac Med Sao Jose do Rio Preto, Pediat & Pediat Surg, Sao Jose Do Rio Preto, SP, Brazil
Ferdinando, Danielle Lopes Teixeira
[1
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Fraga, Fernanda Del Campo Braojos
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Fac Med Sao Jose do Rio Preto, Image Unit, Sao Jose Do Rio Preto, SP, BrazilFac Med Sao Jose do Rio Preto, Pediat & Pediat Surg, Sao Jose Do Rio Preto, SP, Brazil
Fraga, Fernanda Del Campo Braojos
[2
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Piatto, Vania Belintani
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Fac Med Sao Jose do Rio Preto, Anat Unit, Sao Jose Do Rio Preto, SP, BrazilFac Med Sao Jose do Rio Preto, Pediat & Pediat Surg, Sao Jose Do Rio Preto, SP, Brazil
Piatto, Vania Belintani
[3
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Souza, Antonio Soares
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Fac Med Sao Jose do Rio Preto, Image Unit, Sao Jose Do Rio Preto, SP, BrazilFac Med Sao Jose do Rio Preto, Pediat & Pediat Surg, Sao Jose Do Rio Preto, SP, Brazil
Souza, Antonio Soares
[2
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机构:
[1] Fac Med Sao Jose do Rio Preto, Pediat & Pediat Surg, Sao Jose Do Rio Preto, SP, Brazil
[2] Fac Med Sao Jose do Rio Preto, Image Unit, Sao Jose Do Rio Preto, SP, Brazil
[3] Fac Med Sao Jose do Rio Preto, Anat Unit, Sao Jose Do Rio Preto, SP, Brazil
来源:
ABCD-ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA-BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY
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2022年
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35卷
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01期
<bold>Background: </bold>Abnormalities in the different stages of the intestinal maturation process cause metabolic and molecular changes. Among the genetic alterations associated with necrotizing enterocolitis, the -94ins/delATTG polymorphism in NFKB1 gene leads to unregulated activation of the NFKB protein due to an increase in the inherent pro-inflammatory state of the premature intestine.<bold>Aims: </bold>To determine the prevalence of the -94ins/delATTG polymorphism in NFKB1 gene in neonates with and without necrotizing enterocolitis.<bold>Methods: </bold>This is a case-control study, in which 25 neonates were evaluated as the case group and 50 neonates as the control group, of both genders. DNA was extracted from peripheral blood leukocytes, and the site encompassing the polymorphism was amplified by molecular techniques (polymerase chain reaction/polymorphism in restriction fragment length).<bold>Results: </bold>Necrotizing enterocolitis was diagnosed in 25 (33%) neonates and, of these, 3 (12%) died. Male gender was more prevalent in both groups (p=0.1613): cases (52%) and controls (62%). Moderate and extreme preterm newborns were predominant in both groups: cases (80%) and controls (88%) (p=0.3036). Low birth weight and extremely low birth weight newborns were the most prevalent in cases (78%), and very low birth weight and extremely low birth weight were the most prevalent in controls (81%) (p=0.1073). Clinical treatment was successful in 72%, and hospital discharge was achieved in 88% of newborns with NEC. The -94ins/delATTG polymorphism in NFKB1 gene was not identified in all the 150 alleles analyzed (100%).<bold>Conclusions: </bold>The absence of the -94ins/delATTG polymorphism in NFKB1 gene in newborns with and without necrotizing enterocolitis does not rule out the possibility of alterations in this and/or in other genes in newborns with this condition, which reinforces the need for further research
机构:
Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Luo, Jun-Yi
Li, Yan-Hong
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Xinjiang Med Univ, Dept Med Sci Examinat Ctr, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Li, Yan-Hong
Fang, Bin-Bin
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Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Fang, Bin-Bin
Tian, Ting
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Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Tian, Ting
Liu, Fen
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Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Liu, Fen
Li, Xiao-Mei
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Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Li, Xiao-Mei
Gao, Xiao-Ming
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Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Xinjiang Key Lab Med Anim Model Res, Urumqi, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
Gao, Xiao-Ming
Yang, Yi-Ning
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机构:
Xinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R ChinaXinjiang Med Univ, State Key Lab Pathogenesis Prevent & Treatment Hi, Dept Cardiol, Affiliated Hosp 1, 137 Liyushan South Rd, Urumqi 830054, Xinjiang, Peoples R China
机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology
Jun-Yi Luo
Yan-Hong Li
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机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology
Yan-Hong Li
Bin-Bin Fang
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机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology
Bin-Bin Fang
Ting Tian
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机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology
Ting Tian
Fen Liu
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机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology
Fen Liu
Xiao-Mei Li
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机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology
Xiao-Mei Li
Xiao-Ming Gao
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机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology
Xiao-Ming Gao
Yi-Ning Yang
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机构:First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology