IS -94INS/DELATTG POLYMORPHISM IN THE NUCLEAR FACTOR KAPPA-B1 GENE (NFKB1) ASSOCIATED WITH NECROTIZING ENTEROCOLITIS?

被引:0
|
作者
Ferdinando, Danielle Lopes Teixeira [1 ]
Fraga, Fernanda Del Campo Braojos [2 ]
Piatto, Vania Belintani [3 ]
Souza, Antonio Soares [2 ]
机构
[1] Fac Med Sao Jose do Rio Preto, Pediat & Pediat Surg, Sao Jose Do Rio Preto, SP, Brazil
[2] Fac Med Sao Jose do Rio Preto, Image Unit, Sao Jose Do Rio Preto, SP, Brazil
[3] Fac Med Sao Jose do Rio Preto, Anat Unit, Sao Jose Do Rio Preto, SP, Brazil
来源
ABCD-ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA-BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY | 2022年 / 35卷 / 01期
关键词
Enterocolitis; Necrotizing Infant; Premature Nf-kappa B Polymorphism; Genetic; PATHOGENESIS; NEC; MORTALITY; INSIGHTS; IMPACT;
D O I
10.1590/0102-672020220002e1717
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
<bold>Background: </bold>Abnormalities in the different stages of the intestinal maturation process cause metabolic and molecular changes. Among the genetic alterations associated with necrotizing enterocolitis, the -94ins/delATTG polymorphism in NFKB1 gene leads to unregulated activation of the NFKB protein due to an increase in the inherent pro-inflammatory state of the premature intestine.<bold>Aims: </bold>To determine the prevalence of the -94ins/delATTG polymorphism in NFKB1 gene in neonates with and without necrotizing enterocolitis.<bold>Methods: </bold>This is a case-control study, in which 25 neonates were evaluated as the case group and 50 neonates as the control group, of both genders. DNA was extracted from peripheral blood leukocytes, and the site encompassing the polymorphism was amplified by molecular techniques (polymerase chain reaction/polymorphism in restriction fragment length).<bold>Results: </bold>Necrotizing enterocolitis was diagnosed in 25 (33%) neonates and, of these, 3 (12%) died. Male gender was more prevalent in both groups (p=0.1613): cases (52%) and controls (62%). Moderate and extreme preterm newborns were predominant in both groups: cases (80%) and controls (88%) (p=0.3036). Low birth weight and extremely low birth weight newborns were the most prevalent in cases (78%), and very low birth weight and extremely low birth weight were the most prevalent in controls (81%) (p=0.1073). Clinical treatment was successful in 72%, and hospital discharge was achieved in 88% of newborns with NEC. The -94ins/delATTG polymorphism in NFKB1 gene was not identified in all the 150 alleles analyzed (100%).<bold>Conclusions: </bold>The absence of the -94ins/delATTG polymorphism in NFKB1 gene in newborns with and without necrotizing enterocolitis does not rule out the possibility of alterations in this and/or in other genes in newborns with this condition, which reinforces the need for further research
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页数:6
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