Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placenta

被引：14

作者：

Vilahur, Nadia ^{[1
,2
,3
,4
]}

Bustamante, Mariona ^{[1
,2
,3
,4
]}

Morales, Eva ^{[1
,3
,5
]}

Motta, Valeria ^{[6
]}

Fatima Fernandez, Mariana ^{[3
,7
,8
]}

Andres Salas, Lucas ^{[1
,2
,3
]}

Escaramis, Georgia ^{[3
,4
]}

Ballester, Ferran ^{[3
,9
,10
]}

Murcia, Mario ^{[3
,9
]}

Tardon, Adonina ^{[3
,11
]}

Riano, Isolina ^{[3
,12
]}

Santa-Marina, Loreto ^{[3
,13
,14
]}

Ibarluzea, Jesus ^{[3
,13
,14
]}

Pedro Arrebola, Juan ^{[3
,7
,8
]}

Estivill, Xavier ^{[2
,3
,4
,15
]}

Bollati, Valentina ^{[6
]}

Sunyer, Jordi ^{[1
,2
,3
,15
]}

Olea, Nicolas ^{[3
,7
,8
]}

机构：

[1] Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain

[2] UPF, Barcelona, Spain

[3] CIBERESP, Barcelona, Spain

[4] Ctr Genom Regulat CRG, Genom & Dis Grp, Bioinformat & Genom Program, Barcelona, Spain

[5] Virgen Arrixaca Univ Hosp, IMIB Arrixaca Res Inst, Murcia, Spain

[6] Univ Milan, Dept Clin Sci & Community Hlth, EPIGET Epidemiol Epigenet & Toxicol Lab, Milan, Italy

[7] Univ Granada, Dept Radiol, E-18071 Granada, Spain

[8] Inst Invest Biosanitaria, Ibs Granada, Spain

[9] Univ Jaume 1, FISABIO Univ Valencia, Joint Res Unit Epidemiol & Environm Hlth, Valencia, Spain

[10] Univ Valencia, Valencia, Spain

[11] Univ Oviedo, Oviedo, Asturias, Spain

[12] SESPA, Hosp San Agustin, Asturias, Spain

[13] Biodonostia, Hlth Res Inst, San Sebastian, Spain

[14] Govt Basque Country, Dept Hlth, Publ Hlth Gipuzkoa, San Sebastian, Spain

[15] Hosp Mar Res Inst IMIM, Barcelona, Spain

来源：

EPIGENOMICS | 2016年 / 8卷 / 01期

关键词：

DNA methylation; endocrine disruptors; epigenome xenoestrogens; placenta; prenatal; programming; TEXB; ENDOCRINE-DISRUPTING CHEMICALS; IN-UTERO EXPOSURE; ARSENIC EXPOSURE; POLYCHLORINATED-BIPHENYLS; EPIGENETIC MECHANISM; GENE-EXPRESSION; CORD BLOOD; ESTROGEN; HEALTH; DIETHYLSTILBESTROL;

D O I：

10.2217/epi.15.91

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: In utero exposure to xenostrogens may modify the epigenome. We explored the association of prenatal exposure to mixtures of xenoestrogens and genome-wide placental DNA methylation. Materials & methods: Sex-specific associations between methylation changes in placental DNA by doubling the concentration of TEXB-alpha exposure were evaluated by robust multiple linear regression. Two CpG sites were selected for validation and replication in additional male born placentas. Results: No significant associations were found, although the top significant CpGs in boys were located in the LRPAP1, HAGH, PPARGC1B, KCNQ1 and KCNQ1DN genes, previously associated to birth weight, Type 2 diabetes, obesity or steroid hormone signaling. Neither technical validation nor biological replication of the results was found in boys for LRPAP and PPARGC1B. Conclusion: Some suggestive genes were differentially methylated in boys in relation to prenatal xenoestrogen exposure, but our initial findings could not be validated or replicated.

引用

页码：43 / 54

页数：12

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