Di-tert-butyl N,N-diethylphosphoramidite as an Air Stable Ligand for Suzuki-Miyaura and Buchwald-Hartwig Reactions

被引：7

作者：

Ilie, Adriana ^{[1
,2
]}

Roiban, Gheorghe-Doru ^{[1
,2
,3
]}

Reetz, Manfred T. ^{[1
,2
]}

机构：

[1] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany

[2] Philipps Univ, Fachbereich Chem, Hans Meerwein Str, D-35032 Marburg, Germany

[3] GlaxoSmithKline Plc, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 04期

关键词：

amination; homogenous catalysis; P ligand; palladium; Suzuki cross-coupling; CROSS-COUPLING REACTIONS; PALLADIUM-CATALYZED AMINATION; ARYL CHLORIDES; NOBEL LECTURE; HALIDES; AMINES; PERSPECTIVE; ARYLATIONS; MESYLATES; AMMONIA;

D O I：

10.1002/slct.201700086

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe herein an air stable phosphorus ligand for both Suzuki-Miyaura and Buchwald-Hartwig palladium-catalyzed cross coupling reactions. The versatility of the Pd(dba)(2)-di-tert-butyl N,N-diethylphosphoramidite catalytic system is demonstrated for a variety of aryl and heteroaryl halides. This ligand is '' bench stable '' which allows easy catalyst preparation. Moreover, even at low catalyst loadings (0.5 %), excellent yields are usually achieved.

引用

页码：1392 / 1397

页数：6

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