Stem cell transplant in MF: it's time to personalize

被引：18
|
作者：
Passamonti, Francesco [1 ]
机构：
[1] Univ Insubria, Varese Va, Italy
来源：
BLOOD | 2019年 / 133卷 / 20期
关键词：
PROGNOSTIC MODEL; PREDICT SURVIVAL;
D O I：
10.1182/blood-2019-03-900860
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Gagelmann et al(1) describe an integrated clinical-molecular prognostic model (Myelofibrosis Transplant Scoring System [MTSS]) to predict outcome post stem cell transplant (SCT) in myelofibrosis (MF). MF is a clonal stem cell neoplasm with heterogeneous clinical phenotypes and well-defined driver mutations found in similar to 90% of the cases. (2) Despite the introduction of JAK inhibitors, (3) MF still remains an incurable disease with a median survival of 4 to 5 years. SCT is an option for MF patients, (4) but, because of the very high risk of mortality, the patient selection is very critical.
引用
收藏
页码：2118 / +
页数：5
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