Suppressors of superoxide production from mitochondrial complex III

被引：0

作者：

Orr, Dam L. ^{[1
]}

Vargas, Leonardo ^{[2
]}

Turk, Carolina N. ^{[2
]}

Baaten, Janine E. ^{[2
]}

Matzen, Jason T. ^{[2
]}

Dardov, Victoria J. ^{[2
]}

Attle, Stephen J. ^{[2
]}

Li, Jing ^{[2
]}

Quackenbush, Douglas C. ^{[2
]}

Goncalves, Renata L. S. ^{[1
]}

Perevoshchikova, Irina V. ^{[1
]}

Petrassi, H. Michael ^{[2
]}

Meeusen, Shelly L. ^{[2
]}

Ainscow, Edward K. ^{[2
]}

Brand, Martin D. ^{[1
]}

机构：

[1] Buck Inst Res Aging, Novato, CA USA

[2] Novartis Res Fdn, Genom Inst, San Diego, CA USA

来源：

NATURE CHEMICAL BIOLOGY | 2015年 / 11卷 / 11期

基金：

美国国家卫生研究院;

关键词：

OXYGEN SPECIES GENERATION; T-CELL-ACTIVATION; OXIDATIVE STRESS; ROS PRODUCTION; RESPIRATION; INHIBITION; MECHANISM; TOXICITY; DEATH; RATES;

D O I：

10.1038/NCHEMBIO.1910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.

引用

页码：834 / U36

页数：6

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