Gene expression profile in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia

被引：11
|
作者：
Alonso, Vivian [1 ]
Neves, Adriana F. [1 ]
Marangoni, Karina [1 ]
Faria, Paula C. B. [1 ]
Freschi, Ana Paula P. [1 ]
Capaneli, Andreia C. [1 ]
Meola, Juliana [1 ]
Goulart, Luiz R. [1 ]
机构：
[1] Univ Fed Uberlandia, Inst Genet & Biochem, Lab Nanobiotechnol, BR-38400902 Uberlandia, MG, Brazil
来源：
CANCER DETECTION AND PREVENTION | 2009年 / 32卷 / 04期
关键词：
Gene expression; Slot-blot array; Prostate cancer; Peripheral blood;
D O I：
10.1016/j.cdp.2008.10.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells. Methods: The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Results: Messenger RNA from patient's blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa 5.8-fold higher than BPH disease. Conclusion: The NOS3 gene expression in the patient's blood may be used as a putative biomarker for prostate cancer. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：336 / 337
页数：2
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