Role of curdlan sulfate in the binding of HIV-1 gp120 to CD4 molecules and the production of gp120-mediated TNF-alpha

被引：24
|
作者：
TakedaHirokawa, N
Neoh, LP
Akimoto, H
Kaneko, H
Hishikawa, T
Sekigawa, I
Hashimoto, H
Hirose, S
Murakami, T
Yamamoto, N
Mimura, T
Kaneko, Y
机构：
[1] JUNTENDO UNIV, IZUNAGAOKA HOSP, DEPT MED, SHIZUOKA 41022, JAPAN
[2] JUNTENDO UNIV, SCH MED, DEPT RHEUMATOL & INTERNAL MED, BUNKYO KU, TOKYO 113, JAPAN
[3] AJINOMOTO CO INC, CHUO KU, TOKYO 104, JAPAN
[4] TOKYO MED & DENT UNIV, SCH MED, DEPT MICROBIOL, BUNKYO KU, TOKYO 113, JAPAN
来源：
MICROBIOLOGY AND IMMUNOLOGY | 1997年 / 41卷 / 09期
关键词：
HIV-1; gp120; curdlan sulfate; TNF-alpha;
D O I：
10.1111/j.1348-0421.1997.tb01920.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To clarify the mechanism by which curdlan sulfate (CRDS) inhibits human immunodeficiency virus (HIV)-1 infection, we examined its influence on the binding of gp120 to CD4 molecules on T cells and macrophages, as well as on the production of TNF-alpha by gp120-stimulated macrophages (which promotes HIV-1 replication). CRDS treatment of cells not only inhibited the binding of HIV-1 gp120 to CD4(+) cells, but also inhibited TNF-alpha production induced by gp120. Inhibition of HIV-1 infection by CRDS may be related to these two actions.
引用
收藏
页码：741 / 745
页数：5
相关论文
共 50 条
  • [41] Synthetic peptides representing discontinuous CD4 binding epitopes of HIV-1 gp120 that induce T cell apoptosis and block cell death induced by gp120
    Howie, SEM
    Cotton, GJ
    Heslop, I
    Martin, NJ
    Harrison, DJ
    Ramage, R
    FASEB JOURNAL, 1998, 12 (11): : 991 - 998
  • [42] Structure-based design of peptides that recognize the CD4 binding domain of HIV-1 gp120
    Fontenot, JD
    Tan, X
    Phillips, DM
    AIDS, 1998, 12 (12) : 1413 - 1418
  • [43] Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues
    Yu, Xiaobo
    Talukder, Poulami
    Bhattacharya, Chandrabali
    Fahmi, Nour Eddine
    Lines, Jamie A.
    Dedkova, Larisa M.
    LaBaer, Joshua
    Hecht, Sidney M.
    Chen, Shengxi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (24) : 5699 - 5703
  • [44] RECOMBINANT HUMAN-ANTIBODY FRAGMENTS TO THE HIV-1 GP120 CD4 BINDING-SITE
    WATKINS, BA
    DAVIS, AE
    FIORENTINI, S
    REITZ, MS
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 : S134 - S134
  • [45] OLIGOSACCHARIDE-MEDIATED INTERACTIONS OF THE ENVELOPE GLYCOPROTEIN GP120 OF HIV-1 THAT ARE INDEPENDENT OF CD4 RECOGNITION
    LARKIN, M
    CHILDS, RA
    MATTHEWS, TJ
    THIEL, S
    MIZUOCHI, T
    LAWSON, AM
    SAVILL, JS
    HASLETT, C
    DIAZ, R
    FEIZI, T
    AIDS, 1989, 3 (12) : 793 - 798
  • [46] HIV-1 Resistance to Maraviroc Conferred by a CD4 Binding Site Mutation in the Envelope Glycoprotein gp120
    Ratcliff, Annette N.
    Shi, Wuxian
    Arts, Eric J.
    JOURNAL OF VIROLOGY, 2013, 87 (02) : 923 - 934
  • [47] HIV REQUIRES MULTIPLE GP120 MOLECULES FOR CD4-MEDIATED INFECTION
    LAYNE, SP
    MERGES, MJ
    DEMBO, M
    SPOUGE, JL
    NARA, PL
    NATURE, 1990, 346 (6281) : 277 - 279
  • [48] The first structure of HIV-1 gp120 with CD4 and CCR5 receptors
    Guan, Yongjun
    CELL AND BIOSCIENCE, 2019, 9 (1):
  • [49] Inhibition of human immunodeficiency virus type 1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120
    Hioe, CE
    Tuen, M
    Chien, PC
    Jones, G
    Ratto-Kim, S
    Norris, PJ
    Moretto, WJ
    Nixon, DF
    Gorny, MK
    Zolla-Pazner, S
    JOURNAL OF VIROLOGY, 2001, 75 (22) : 10950 - 10957
  • [50] The first structure of HIV-1 gp120 with CD4 and CCR5 receptors
    Yongjun Guan
    Cell & Bioscience, 9
12345