Human papillomavirus status in extragenital nonmelanoma skin cancers

被引：8

作者：

Drvar, Daniela Ledic ^{[1
]}

Lipozencic, Jasna ^{[2
]}

Sabol, Ivan ^{[3
]}

Mokos, Zrinka Bukvic ^{[1
]}

Ilic, Ivana ^{[4
,5
]}

Grce, Magdalena ^{[3
]}

机构：

[1] Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Dept Dermatol & Venereol, Zagreb 10000, Croatia

[2] Croatian Acad Med Sci, Zagreb 10000, Croatia

[3] Rudjer Boskovic Inst, Dept Mol Med, Zagreb 10000, Croatia

[4] Univ Zagreb, Zagreb Univ Hosp Ctr, Dept Pathol & Cytol, Zagreb 10000, Croatia

[5] Univ Zagreb, Sch Med, Zagreb 10000, Croatia

来源：

CLINICS IN DERMATOLOGY | 2014年 / 32卷 / 02期

关键词：

SQUAMOUS-CELL CARCINOMA; BASAL-CELL; INFECTION; HPV; DNA; EXPOSURE; CROATIA;

D O I：

10.1016/j.clindermatol.2013.08.009

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs); namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common malignancies in Caucasians. In fact, there is an intense connection between sunlight exposure, fair skin, HPV, and development of NMSC. We have conducted a pilot study that included tissue samples from 26 carcinoma patients, of which there were 13 BCC and 13 SCC. HPV detection and typing was done with DNA amplification and sequencing, respectively. In total, 23.1% of SCC samples (3/13) and 7.7% of BCC samples (1/13) were positive for HPV DNA. The importance of understanding all aspects of NMSC carcinogenesis may be to reveal novel therapeutic options or preventive measures for HPV containing NMSC patients. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：248 / 252

页数：5

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