Alkylation of pyrimido[5′,4′:5,6]pyrido[3,2-b]indol-4-one derivatives

被引：1

作者：

Masterova, N. S. ^{[1
]}

Alekseeva, L. M. ^{[1
]}

Shashkov, A. S. ^{[2
]}

Tafeenko, V. A. ^{[3
]}

Ryabova, S. Yu. ^{[1
]}

Granik, V. G. ^{[1
]}

机构：

[1] State Res Ctr Antibiot, Moscow 117003, Russia

[2] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

[3] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2008年 / 57卷 / 08期

关键词：

11-benzyl-3,11-dihydro-4H-pyrimido[5 ',4 ':5,6]pyrido[3,2-b]indol-4-one; X-ray diffraction analysis; alkylation; 3-and 6-monoalkylpyrimido[5 ',4 ':5,6]pyrido[3,2-b]indol-4-ones; 3,6-dialkylpyrimido[5 ',4 ':5,6]pyrido[3,2-b]indol-4-ones; halides;

D O I：

10.1007/s11172-008-0234-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alkylation of 11-benzyl-3,11-dihydro-4H-pyrimido[5',4':5,6]pyrido[3,2-b]indol-4-one with methyl iodide and methyl bromoacetate in DMF gave 3-alkylpyrimidopyridoindolones as the corresponding salts. The reaction in acetone in the presence of K2CO3 yielded 3,6-disubstitution products. Alkylation with DMF dimethyl acetal gave a mixture of the 3- and 6-alkylpyrimidopyridoindol-4-one bases. The structure of 4-oxo-4,6-dihydro-3H-pyrimido-[5',4':5,6]pyrido[3,2-b]indol-11-ium chloride (3b) was proved by X-ray diffraction analysis.

引用

页码：1765 / 1772

页数：8

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