Induction of GM-CSF production of macrophages by advanced glycation end products of the Maillard reaction

被引：11

作者：

Sasaki, T

Horiuchi, S

Yamazaki, M

Yui, S ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 1990195, Japan

[2] Kumamoto Univ, Sch Med, Dept Biochem, Kumamoto 8600811, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1999年 / 63卷 / 11期

关键词：

GM-CSF; advanced glycation end products; macrophage growth;

D O I：

10.1271/bbb.63.2011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously reported that AGEs can induce macrophage growth. In this paper, we examined whether advanced glycation end products (AGE) of protein induced GM-CSF production of macrophages. AGE of bovine serum albumin markedly stimulated not only the expression of GM-CSF mRNA, but also GM-CSF secretion in macrophage supernatant. Thus GM-CSF is suggested to be an endogenous signal for macrophage growth induction by AGEs.

引用

页码：2011 / 2013

页数：3

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