Hemodynamic improvement of acutely decompensated heart failure patients is associated with decreasing levels of NT-proBNP

被引：3
|
作者：
Knebel, Fabian [1 ]
Schimke, Ingolf [1 ]
Ramirez, Ivan Diaz [1 ]
Schattke, Sebastian [1 ]
Eddicks, Stephan [1 ]
Borges, Adrian C. [1 ]
Baumann, Gert [1 ]
机构：
[1] Univ Med Berlin, Charite Campus Mitte, Med Clin Cardiol & Angiol, D-10098 Berlin, Germany
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 134卷 / 02期
关键词：
Acute heart failure; Intensive care; Natriuretic peptides; NT-proBNP; Invasive hemodynamics; BRAIN NATRIURETIC PEPTIDE; BIOLOGICAL VARIATION; CARE; CATHETERIZATION; ADMISSION; DIAGNOSIS; DISEASE; ASSAY;
D O I：
10.1016/j.ijcard.2007.12.106
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Successful therapy in chronic clinically stable heart failure is reflected by decreasing serum NT-proBNP levels. This study evaluates therapymonitoring by NT-proBNP in comparison to invasively measured hemodynamic parameters in acutely decompensated heart failure patients. Methods and results: In 25 acutely decompensated chronic heart failure patients (NYHA III-IV, Cardiac Index (CI)<= 2.5 l/min/m(2) and a PCWP >= 15 mm Hg) changes in NT-proBNP and invasive hemodynamics were compared. Hemodynamic improvement in the first 24 h (CI >= 30% and PCWP <= 30%, compared to baseline) was associated with decreasing NT-proBNP levels; which was not seen in patients without hemodynamic improvement. To discriminate between responders and non-responders, a decline to < 80% of the baseline NT-proBNP in the first 24 h was the best cut-off. Conclusion: Hemodynamic improvement in acutely decompensated heart failure patients is associated with decreasing NT-proBNP levels. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：260 / 263
页数：4
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