Syntheses of [1-15N]-2'-deoxyinosine, [4-15N]-2'-deoxyAICAR, and [1-15N]-2'-deoxyguanosine

被引：0

作者：

Catalanotti, B

De Napoli, L

Galeone, A

Mayol, L

Oliviero, G

Piccialli, G

Varra, M

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Chim Organ & Biol, I-80134 Naples, Italy

[3] Univ Molise, Fac Sci, I-86170 Isernia, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 1999卷 / 09期

关键词：

labeled deoxyinosine; labeled deoxyAICAR; labeled deoxyguanosine; purine rearrangement; labeled nucleosides;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A high-yield synthesis of [1-N-15]-2'-deoxyinosine (5), [4-N-15]-2'-deoxy AICAR (7), and [1-N-15]-2'-deoxyguanosine (10) from 2'-deoxyinosine (1) using relatively low expensive (NH3)-N-15 as N-15 source is described. The method exploits 2-C reactivity of 2'-deoxyinosine (1) to obtain its N-15-labelled counterpart, through [1-N-15]-2'-deoxyinosine (5), and successively, [4-N-15]-2'-deoxyAICAR (7). [1-N-15]-2'-Deoxyguanosine (10) can be prepared as well, through an improved cyclization procedure. No protection of sugar hydroxyl groups is required at any stage.

引用

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页码：2235 / 2239

页数：5

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