CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression

被引：76
|
作者：
Kong, Yanan [1 ,2 ,3 ]
Yang, Lu [1 ,2 ,3 ]
Wei, Weidong [1 ,2 ,3 ]
Lyu, Ning [2 ,3 ,4 ]
Zou, Yutian [1 ,2 ,3 ]
Gao, Guanfeng [1 ,2 ,3 ]
Ou, Xueqi [1 ,2 ,3 ]
Xie, Xiaoming [1 ,2 ,3 ]
Tang, Hailin [1 ,2 ,3 ]
机构：
[1] Sun Yat Sen Univ, Canc Ctr, Dept Breast Oncol, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[2] State Key Lab Oncol South China, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[3] Collaborat Innovat Ctr Canc Med, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Dept Minimally Invas Intervent Radiol, Canc Ctr, 651 East Dongfeng Rd, Guangzhou, Guangdong, Peoples R China
来源：
EPIGENOMICS | 2019年 / 11卷 / 10期
基金：
中国国家自然科学基金;
关键词：
ceRNAs; circPLK1; circRNAs; MiR-296-5p; miRNAs; PLK1; prognosis; therapy; triple-negative breast cancer; tumor occurrence and metastasis; POLO-LIKE KINASE; POTENTIAL THERAPEUTIC TARGET; SMALL-MOLECULE INHIBITOR; CIRCULAR RNAS; PROGNOSTIC-SIGNIFICANCE; PLK EXPRESSION; GROWTH; IDENTIFICATION; MARKER;
D O I：
10.2217/epi-2019-0093
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. Materials & methods: We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments in vitro and in vivo were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and PLK1 in TNBC. Results & conclusion: CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion in vitro as well as tumor occurrence and metastasis in vivo. CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.
引用
收藏
页码：1163 / 1176
页数：14
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