Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation

被引：15
|
作者：
Mizuguchi, Takaaki [2 ]
Uchimura, Hiromasa [1 ]
Kakizawa, Taeko [2 ]
Kimura, Tooru [2 ]
Yokoyama, Shigeyuki [3 ]
Kiso, Yoshiaki [2 ]
Saito, Kazuki [1 ,3 ,4 ]
机构：
[1] Kyoto Pharmaceut Univ, Lab Prote Sci, 21st Century COE Program, Yamashina Ku, Kyoto 6078412, Japan
[2] Kyoto Pharmaceut Univ, Dept Med Chem, Ctr Frontier Res Med Sci, Yamashina Ku, Kyoto 6078412, Japan
[3] RIKEN Syst & Struct Biol Ctr, Yokohama, Kanagawa 2300045, Japan
[4] Univ Tokyo, Grad Sch Sci, Dept Biophys & Biochem, Bunkyo Ku, Tokyo 1130033, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 12期
关键词：
A431; cells; Autophosphorylation; Dimerization-arm-mimetic peptide; Dimerization inhibitor; EGF receptor; EPIDERMAL-GROWTH-FACTOR; METASTATIC COLORECTAL-CANCER; COST-EFFECTIVENESS ANALYSIS; TYROSINE KINASE INHIBITOR; CELL LUNG; MODEL; OVEREXPRESSION; ANTIBODY; IRESSA;
D O I：
10.1016/j.bmcl.2009.04.080
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A cyclic decapeptide was chemically synthesized that mimics the loop structure of a beta-hairpin arm of the EGF receptor, which is highly involved in receptor dimerization upon activation by ligand binding. This peptide was revealed to reduce dimer formation of the receptor in a detergent-solubilized extract of epidermoid carcinoma A431 cells and to inhibit receptor autophosphorylation at less than 10 mu M in the intact cells. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3279 / 3282
页数：4
相关论文
共 50 条
  • [21] Controlling epidermal growth factor (EGF)-stimulated ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor
    Rojas, M
    Yao, SY
    Lin, YZ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (44) : 27456 - 27461
  • [22] The peptide YYY1 receptor couples to MAPK activation via the EGF receptor, an epithelial cell specific pathway.
    Mannon, PJ
    MacIntyre, N
    [J]. GASTROENTEROLOGY, 1999, 116 (04) : A625 - A625
  • [23] The Trophic Effect of Ouabain on Retinal Ganglion Cell is Mediated by EGF Receptor and PKC δ Activation
    Correa, Gustavo de Rezende
    da Silva Cunha, Karinne Cristinne
    dos Santos, Aline Araujo
    de Araujo, Elizabeth Giestal
    [J]. NEUROCHEMICAL RESEARCH, 2010, 35 (09) : 1343 - 1352
  • [24] The Trophic Effect of Ouabain on Retinal Ganglion Cell is Mediated by EGF Receptor and PKC δ Activation
    Gustavo de Rezende Corrêa
    Karinne Cristinne da Silva Cunha
    Aline Araujo dos Santos
    Elizabeth Giestal de Araujo
    [J]. Neurochemical Research, 2010, 35 : 1343 - 1352
  • [25] The inhibitory effect of an EGF receptor-specific tyrosine kinase inhibitor on pancreatic cancer cell lines was more potent than inhibitory antibodies against the receptors for EGF and IGF 1
    Kobari, M
    Kullenberg, B
    Björkman, A
    Matsuno, S
    Ihse, I
    Axelson, J
    [J]. INTERNATIONAL JOURNAL OF PANCREATOLOGY, 1998, 24 (02) : 85 - 95
  • [26] The inhibitory effect of an EGF receptor-specific tyrosine kinase inhibitor on pancreatic cancer cell lines was more potent than inhibitory antibodies against the receptors for EGF and IGF I
    Masao Kobari
    Björn Kullenberg
    Anders Björkman
    Seiki Matsuno
    Ingemar Ihse
    Jan Axelson
    [J]. International journal of pancreatology, 1998, 24 (2) : 85 - 95
  • [27] The activation of gastric inhibitory peptide/gastric inhibitory peptide receptor axis via sonic hedgehog signaling promotes the bridging of gapped nerves in sciatic nerve injury
    Guan, Tuchen
    Guo, Beibei
    Zhang, Wenxue
    Qi, Mengwei
    Luo, Xiaoqian
    Li, Zhen
    Zhang, Yufang
    Bao, Tiancheng
    Xu, Man
    Liu, Mei
    Liu, Yan
    [J]. JOURNAL OF NEUROCHEMISTRY, 2023, 165 (06) : 842 - 859
  • [28] Inhibitory effect of an altered peptide SUB 268-270 in T cell activation
    Li, ZG
    Chen, YJ
    Zhou, Q
    Lv, HS
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2003, 62 : 381 - 381
  • [29] Tyrosine phosphorylation of EGF receptor, but not activation of MAP kinase and p70S6 kinase, requires growth inhibitory concentration of EGF in A431 cells
    Fukazawa, H
    Mizuno, S
    Uehara, Y
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1997, 8 : 49 - 49
  • [30] Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation
    Zhang, Q
    Thomas, SM
    Lui, VWY
    Xi, S
    Siegfried, JM
    Fan, H
    Smithgall, TE
    Mills, GB
    Grandis, JR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) : 6901 - 6906
12345