Basal insulin requirement of youth with type 1 diabetes differs according to age

被引：4

作者：

Urakami, Tatsuhiko ^{[1
]}

Kuwabara, Remi ^{[1
]}

Habu, Masako ^{[1
]}

Okuno, Misako ^{[1
]}

Suzuki, Junichi ^{[1
]}

Takahashi, Shori ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Pediat, Tokyo, Japan

来源：

JOURNAL OF DIABETES INVESTIGATION | 2014年 / 5卷 / 04期

关键词：

Basal insulin dose; Total insulin dose; Type; 1; diabetes; BODY-MASS INDEX; JAPANESE CHILDREN; ADOLESCENTS; MELLITUS; GLARGINE; INFUSION; PUBERTY;

D O I：

10.1111/jdi.12161

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the percentage of total basal insulin dose to total daily insulin dose (% TBD) among Japanese youth of different ages with type 1 diabetes. The study enrolled 69 patients with type 1 diabetes who were treated with multiple daily injections of insulin. The participants were divided into the following age groups: group A, 0 to <10 years (n = 18); group B, 10 to <20 years (n = 31) and group C, 20 to <25 years (n = 20). We found no difference in the sex ratio, body mass index, and glycated hemoglobin and 2-h postprandial C-peptide levels among the three groups. Participants assigned to group B had a significantly higher percentage of total daily insulin dose than those in group A and group C (49.7 +/- 10.4% vs 38.5 +/- 13.7% and 38.3 +/- 8.2%, P = 0.0005). In conclusion, the basal insulin requirements of Japanese youth with type 1 diabetes might have an age effect that is associated with puberty.

引用

页码：442 / 444

页数：3

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