One-Pot Van Leusen Synthesis of 4,5-Disubstituted Oxazoles in Ionic Liquids

被引：39

作者：

Wu, Bo ^{[1
]}

Wen, Jun ^{[1
]}

Zhang, Ji ^{[1
]}

Li, Jing ^{[1
]}

Xiang, Yong-Zhe ^{[1
]}

Yu, Xiao-Qi ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Sichuan, Peoples R China

来源：

SYNLETT | 2009年 / 03期

关键词：

ionic liquids; van Leusen oxazole synthesis; tosylmethyl isocyanide; halides; aldehydes; CHEMISTRY; SULFONYLMETHYLISOCYANIDES; DERIVATIVES;

D O I：

10.1055/s-0028-1087547

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and mild protocol for the preparation of 4,5-disubstituted oxazoles through an improved one-pot van Leusen oxazole synthesis in ionic liquids is described. The oxazole products were prepared from tosylmethyl isocyanide (TosMIC), aliphatic halides and various aldehydes in high yields. The recovered ionic liquids could be reused as solvent for six runs without significant loss of yields.

引用

页码：500 / 504

页数：5

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