Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor

被引：8
|
作者：
Webb, TR
Moran, T
Huang, CQ
McCarthy, JR
Grigoriadis, DE
Chen, C
机构：
[1] Neurocrine Biosci Inc, Dept Med Chem, San Diego, CA 92121 USA
[2] Neurocrine Biosci Inc, Dept Pharmacol, San Diego, CA 92121 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 15期
关键词：
benzoylpyrimidine; CRF; antagonist;
D O I：
10.1016/j.bmcl.2004.05.072
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of benzoylpyrimidines derived from the anilinepyrimidine CRF1 antagonists were synthesized. Several synthetic routes were developed to explore the SAR of this series of compounds. Compounds such as 8d (K-i = 15 nM) exhibited high binding affinities at the human CRF1 receptor. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3869 / 3873
页数：5
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