The Dynamics of Neuronal Migration

被引：2

作者：

Wu, Qian ^{[1
]}

Liu, Jing ^{[1
]}

Fang, Ai ^{[1
]}

Li, Rui ^{[1
]}

Bai, Ye ^{[1
]}

Kriegstein, Arnold R. ^{[2
,3
]}

Wang, Xiaoqun ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

[2] Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

CELLULAR AND MOLECULAR CONTROL OF NEURONAL MIGRATION | 2014年 / 800卷

关键词：

Neuronal migration; Neural stem cells; Radial Glia; Microtubules; Neuronal migration disorders; Lissencephaly; NEURAL STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; RADIAL GLIAL-CELLS; CORTICAL-NEURONS; PROGENITOR CELLS; CEREBRAL-CORTEX; RAT MODEL; TYROSINE PHOSPHORYLATION; ALZHEIMERS-DISEASE; ADULT BRAIN;

D O I：

10.1007/978-94-007-7687-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Proper lamination of the cerebral cortex is precisely orchestrated, especially when neurons migrate from their place of birth to their final destination. The consequences of failure or delay in neuronal migration cause a wide range of disorders, such as lissencephaly, schizophrenia, autism and mental retardation. Neuronal migration is a dynamic process, which requires dynamic remodeling of the cytoskeleton. In this context microtubules and microtubule- related proteins have been suggested to play important roles in the regulation of neuronal migration. Here, we will review the dynamic aspects of neuronal migration and brain development, describe the molecular and cellular mechanisms of neuronal migration and elaborate on neuronal migration diseases.

引用

页码：25 / 36

页数：12

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