Chiral enol acetates derived from prochiral oxabicyclic ketones using enzymes

被引：10
|
作者：
Carnell, AJ [1 ]
Swain, SA [1 ]
Bickley, JF [1 ]
机构：
[1] Univ Liverpool, Dept Chem, Robert Robinson Labs, Liverpool L69 7ZD, Merseyside, England
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期
关键词：
D O I：
10.1016/S0040-4039(99)01809-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Racemic enol acetates 2-4 and 9 derived from prochiral 8-oxabicyclo[3.2.1]oct-6-en-3-ones have been resolved with good enantioselectivity (E=45, 47, 48 and 7.8, respectively) using silica-adsorbed Humicola sp. lipase and the absolute configuration of enol acetate 2 was determined by X-ray crystallographic analysis of the camphanyl derivative 13. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8633 / 8636
页数：4
相关论文
共 50 条
12345