[1] Chiba Univ, Grad Sch Sci, Chiba, Japan
[2] Yokohama City Univ, Sch Med, Dept Biochem, Yokohama, Kanagawa 232, Japan
[3] Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Tokyo 158, Japan
[4] Kyorin Univ, Sch Med, Dept Chem, Tokyo, Japan
[5] Prote Collaborat Ctr, Tokyo Metropolitan Inst Gerontol, Tokyo, Japan
[6] Mitsubishi Tanabe Pharma Co, Adv Med Res Lab, Osaka, Japan