Synthesis and in vitro anticancer activity of conjugates of MDP with Amino-acridine/acridone derivatives

被引：0
|
作者：
Gozdowska, M [1 ]
Dzierzbicka, K [1 ]
WysockaSkrzela, B [1 ]
Kolodziejczyk, AM [1 ]
机构：
[1] GDANSK TECH UNIV,DEPT DRUG TECHNOL & BIOCHEM,PL-80952 GDANSK,POLAND
来源：
POLISH JOURNAL OF CHEMISTRY | 1997年 / 71卷 / 06期
关键词：
amino-acridine/acridone derivatives; anticancer activity; muramyl dipeptide;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of MDP (muramyl dipeptide) analogues modified at the C-terminus of MDP molecule by the formation of an amide bond between the carboxylic group of isoglutamine and the amine function of the respective derivative of acridine or acridone were synthesized as potential anticancer agents.
引用
收藏
页码：767 / 773
页数：7
相关论文
共 50 条
  • [41] Design, Synthesis, Antimicrobial, and Anticancer Activities of Acridine Thiosemicarbazides Derivatives
    Chen, Rui
    Huo, Lini
    Jaiswal, Yogini
    Huang, Jiayong
    Zhong, Zhenguo
    Zhong, Jing
    Williams, Leonard
    Xia, Xing
    Liang, Yan
    Yan, Zhenshuo
    MOLECULES, 2019, 24 (11):
  • [42] Synthesis of sulpha drug acridine derivatives and their evaluation for anti-inflammatory, analgesic and anticancer activity
    Sondhi, SM
    Johar, M
    Singh, N
    Shukla, R
    Raghubir, R
    Dastidar, SG
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2002, 41 (12): : 2659 - 2666
  • [43] New Salicylanilide Derivatives and Their Peptide Conjugates as Anticancer Compounds: Synthesis, Characterization, and In Vitro Effect on Glioblastoma
    Horvath, Lilla
    Biri-Kovacs, Beata
    Baranyai, Zsuzsa
    Stipsicz, Bence
    Mehes, Elod
    Jezso, Balint
    Kratky, Martin
    Vinsova, Jarmila
    Bosze, Szilvia
    ACS OMEGA, 2024,
  • [44] Synthesis of Dendrimer Conjugates with Naproxen and their Anticancer Activity
    Castillo-Rodriguez, Irving Osiel
    Ramirez-Apan, Teresa
    Martinez-Garcia, Marcos
    CURRENT ORGANIC CHEMISTRY, 2023, 27 (06) : 540 - 545
  • [45] Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity
    Santra, Sougata
    Sharapov, Ainur D.
    Fatykhov, Ramil F.
    Potapova, Anastasya P.
    Khalymbadzha, Igor A.
    Valieva, Maria I.
    Kopchuk, Dmitry S.
    Zyryanov, Grigory V.
    Bunev, Alexander S.
    Melekhin, Vsevolod V.
    Gaviko, Vasiliy S.
    Zonov, Andrey A.
    PHARMACEUTICALS, 2023, 16 (03)
  • [46] The synthesis, structure, electrochemistry and in vitro anticancer activity studies of ferrocenyl-thymine conjugates
    Kowalski, Konrad
    Koceva-Chyla, Aneta
    Pieniazek, Anna
    Bernasinska, Joanna
    Skiba, Joanna
    Rybarczyk-Pirek, Agnieszka J.
    Jozwiak, Zofia
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2012, 700 : 58 - 68
  • [47] Synthesis, Characterization, Cellular Uptake, and In Vitro Anticancer Activity of Fullerenol-Doxorubicin Conjugates
    Xu, Beihua
    Yuan, Li
    Hu, Ying
    Xu, Zhiyuan
    Qin, Jiang-Jiang
    Cheng, Xiang-Dong
    FRONTIERS IN PHARMACOLOGY, 2021, 11
  • [48] Synthesis of new conjugates of MDP and nor-MDP with retro-tuftsin derivatives as potential immunomodulators
    Dzierzbicka, K.
    POLISH JOURNAL OF CHEMISTRY, 2008, 82 (07) : 1431 - 1439
  • [49] Synthesis and evaluation of in vitro anticancer activity of some novel isopentenyladenosine derivatives
    Ottria, Roberta
    Casati, Silvana
    Manzocchi, Ada
    Baldoli, Erika
    Mariotti, Massimo
    Maier, Jeanette A. M.
    Ciuffreda, Pierangela
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (12) : 4249 - 4254
  • [50] Synthesis and in vitro anticancer activity of brevifoliol derivatives substantiated by in silico approach
    Kaur, Ranjeet
    Chattopadhyay, Sunil K.
    Chatterjee, Arnab
    Prakash, Om
    Khan, Feroz
    Suri, Nitasha
    Priya, Dev
    Saxena, A. K.
    MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (09) : 4138 - 4148
12345