Copper-catalyzed synthesis of N-unsubstituted 1,2,3-triazoles from nonactivated terminal alkynes

被引：172
|
作者：
Jin, T [1 ]
Kamijo, S [1 ]
Yamamoto, Y [1 ]
机构：
[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 18期
关键词：
1,2,3-triazoles; alkynes; copper; catalysis; cycloaddition;
D O I：
10.1002/ejoc.20040442
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The [3+2] cycloaddition of nonactivated terminal alkynes and trimethylsilyl azide proceeded smoothly in the presence of Cu-I catalyst and DMF/MeOH, to give the corresponding N-unsubstituted triazoles in good to high yields. The reaction most probably proceeds through the in situ formation of a copper acetylide species and hydrazoic acid, followed by a successive [3+2] cycloaddition reaction. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).
引用
收藏
页码：3789 / 3791
页数：3
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