On-chip electrochemical analysis system using nanoelectrodes and bioelectronic CMOS chip

被引：33

作者：

Zhu, Xiaoshan ^{[1
]}

Ahn, Chong H.

机构：

[1] Univ Cincinnati, Dept Elect & Comp Engn & Comp Sci, MicroSyst & BioMEMS Lab, Cincinnati, OH 45221 USA

[2] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH 45221 USA

[3] Univ Cincinnati, Ctr BioMEMS & Nanobiosyst, Cincinnati, OH 45221 USA

来源：

IEEE SENSORS JOURNAL | 2006年 / 6卷 / 05期

基金：

美国国家科学基金会;

关键词：

bioelectronic complimentary metal-oxide-semiconductor (CMOS) chip; electrochemical analysis; nanoelectrodes; reversible redox species;

D O I：

10.1109/JSEN.2006.881351

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

An electrochemical microanalysis system for reversible redox species determination has been presented. This system consists of a nanoelectrochemical sensor and a complimentary metal-oxide-semiconductor (CMOS) chip for sensor signal interfacing and conditioning. The nanoelectrochemical sensor is an interdigitated array nanoelectrode fabricated using e-beam lithography and ultraviolet lithography. The CMOS chip is designed and fabricated to realize the electrochemical analysis method of sensing, which is a switch-based method. Using this switch-based method, the potential dynamics of the nanoelectrodes is recorded to evaluate the species concentration. Experimental results have shown that the detection limit of this microanalysis system on reversible redox species is in the range of 1-10 nM.

引用

页码：1280 / 1286

页数：7

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