A Study on the Synthesis, Antimicrobial Activity, and Rapd Analysis of 3-phenyl-1,5-bis(4-(trifluoromethyl)phenyl)-1H-pyrazole

被引:0
|
作者
Cetin, Adnan [1 ]
Bozari, Sedat [2 ]
机构
[1] Mus Alparslan Univ, Dept Sci, Mus, Turkey
[2] Mus Alparslan Univ, Dept Mol Biol & Genet, Mus, Turkey
关键词
Antibacterial; Amaranthus retroflexus; Germination experiment; Hordeum vulgare; PCR; Plant; BIOLOGICAL EVALUATION; FOOD SECURITY; CHALCONES; ANTICANCER; PESTICIDES;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
3-phenyl-1,5-bis(4-(trifluoromethyl)phenyl)-1H-pyrazole was synthesized and its structure was characterized by IR, NMR, and Elemental Analysis. The antimicrobial effects of pyrazole were investigated against seven bacteria (Bacillus subtilis ATCC 6633, Staphylococcus aureus 6538, Bacillus megaterium DSM 32 as gram-positive bacteria and Enterobacter aerogenes ATCC 13048, Pseudomonas aeruginosa 9027, Klebsiella pneumoniae RSKK 574 and Escherichia coli ATCC 25922) and three fungi organisms (Candida albicans ATCC 10231, Yarrovia lipolytica and Saccharomyces cerevisiae). Furthermore, the genomic stability values of designed pyrazole were observed in Hordeum vulgare and Amaranthus retroflexus L. from seeds based on random amplified-polymorphic DNA (RAPD) patterns compared to the five primers.
引用
收藏
页码:77 / 83
页数:7
相关论文
共 50 条
  • [41] Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts
    Gein, V. L.
    Bobrovskaya, O. V.
    Russkikh, A. A.
    Novikova, V. V.
    Gein, O. N.
    Karpenko, Yu. N.
    Chashchina, S. V.
    Dmitriev, M. V.
    Yankin, A. N.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (04) : 680 - 688
  • [42] Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
    Wu, Zhibing
    Hu, Deyu
    Kuang, Jiqing
    Cai, Hua
    Wu, Shixi
    Xue, Wei
    MOLECULES, 2012, 17 (12): : 14205 - 14218
  • [43] 2,3-Bis(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)oxirane
    Wang, Lei
    Yoshida, Takuma
    Okamoto, Masashi
    Sakihama, Yasuko
    Hashidoko, Yasuyuki
    Hashimoto, Makoto
    MOLBANK, 2014, (01)
  • [44] Synthesis and Biological Activity of 5-Aryl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-phenyl-1H-pyrazole-3-carboxamides and Their Salts
    V. L. Gein
    O. V. Bobrovskaya
    A. A. Russkikh
    V. V. Novikova
    O. N. Gein
    Yu. N. Karpenko
    S. V. Chashchina
    M. V. Dmitriev
    A. N. Yankin
    Russian Journal of General Chemistry, 2019, 89 : 680 - 688
  • [45] 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-(phenyl-acetamido)1H-pyrazole-3-carbonitrile
    Zhang, XH
    Chen, JZ
    Zhong, P
    Xiao, HP
    Hu, ML
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 : O3676 - O3678
  • [46] 3,4-Dimethyl-1,1-bis[4-(trifluoromethyl)-phenyl]-2,5-dihydro-1H-germole
    Huck, Lawrence A.
    Harrington, Laura E.
    Britten, James F.
    Leigh, William J.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : M1282 - M1283
  • [47] Microwave Assisted Synthesis of 5-[4-(3-Phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole Derivatives and Their Antimicrobial Activity
    Ashok, D.
    Nagaraju, N.
    Lakshmi, B. Vijaya
    Sarasija, M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (09) : 1905 - 1910
  • [48] Microwave Assisted Synthesis of 5-[4-(3-Phenyl-4,5-dihydro-1H-pyrazol-5-yl)phenyl]-1H-tetrazole Derivatives and Their Antimicrobial Activity
    D. Ashok
    N. Nagaraju
    B. Vijaya Lakshmi
    M. Sarasija
    Russian Journal of General Chemistry, 2019, 89 : 1905 - 1910
  • [49] Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles
    Alp, Mehmet
    Goker, Ali Hakan
    Altanlar, Nurten
    TURKISH JOURNAL OF CHEMISTRY, 2014, 38 (01) : 152 - 156
  • [50] Synthesis and antimicrobial activity of 4-[5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl]dihydropyridines and 4-[5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl]-3,4-dihydropyrimidin-2-ones
    Kumar, Rakesh
    Malik, Sakshi
    Chandra, Ramesh
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (05): : 718 - 724