The Santa Lucia Strain of Plasmodium falciparum in Aotus Monkeys

被引:6
|
作者
Collins, William E. [1 ]
Sullivan, Joann S.
Williams, Allison [3 ]
Galland, G. Gale [2 ]
Nace, Douglas
Williams, Tyrone [4 ]
Barnwell, John W.
机构
[1] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Infect Dis, US Publ Hlth Serv, Chamblee, GA 30341 USA
[2] Ctr Dis Control & Prevent, Geog Med & Hlth Promot Branch, Natl Ctr Preparedness Detect & Control Infect, US Publ Hlth Serv, Atlanta, GA 30333 USA
[3] Ctr Dis Control & Prevent, Anim Resources Branch, Natl Ctr Preparedness Detect & Control Infect, US Publ Hlth Serv, Atlanta, GA 30333 USA
[4] Atlanta Res & Educ Fdn, VA Med Ctr, Atlanta, GA 30033 USA
来源
关键词
EL-SALVADOR STRAIN; ANOPHELES-ALBIMANUS; PUPAL PHENOTYPES; STAGE VACCINES; VIVAX; SUSCEPTIBILITY; INFECTION; NANCYMAI; MODEL; VOCIFERANS;
D O I
10.4269/ajtmh.2009.80.536
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The Santa Lucia strain of Plasmodium falciparum was studied in 150 Aotus lemurinus griseimembra, 30 A. azarae boliviensis, 103 A. nancymaae, and 121 A. vociferans monkeys. All four of these splenectomized hosts supported the production of gametocytes infective to Anopheles freeborni mosquitoes. Transmission through sporozoites from An. freeborni, An. stephensi, An. maculatus, and An. albimanus mosquitoes was successful to all four species of Aotus on a total of 100 occasions with a median pre-patent period of 21 days. For the production of infective mosquitoes for vaccine challenge studies, A. l. griseimembra and A. vociferans were the most predictable hosts.
引用
收藏
页码:536 / 540
页数:5
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