Demethylating agent 5-aza-2′-deoxycytidine activates HLA-G expression in human leukemia cell lines

被引：25

作者：

Polakova, K. ^{[2
]}

Bandzuchova, E. ^{[3
]}

Kuba, D. ^{[3
]}

Russ, G. ^{[1
]}

机构：

[1] Slovak Acad Sci, Inst Virol, Bratislava 84505, Slovakia

[2] Slovak Acad Sci, Canc Res Inst, Bratislava 84505, Slovakia

[3] Slovak Med Univ, Bratislava, Slovakia

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 04期

关键词：

HLA-G; Leukemia cells; Demethylation; 5-Aza-2 '-deoxycytidine; CHRONIC LYMPHOCYTIC-LEUKEMIA; TUMOR-CELLS; G GENE; PROMOTER REGION; CANCER; DNA; DECITABINE; INHIBITORS; PROTEINS;

D O I：

10.1016/j.leukres.2008.08.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HLA-G is a non-classical HLA class I antigen primarily expressed in the extravillous cytotrophoblast. HLA-G can also be expressed at some pathological circumstances and may thus contribute to inhibition of efficient immune responses. Complex regulation of HLA-G expression also involves epigenetic mechanisms as DNA methylation. Here we demonstrate that treatment with demethylating agent 5-aza-2'-deoxycytidine (AdC) resulted in HLA-G transcription in 18 out of 20 examined leukemia cell lines. FILA-G protein synthesis was detected in 10 cell lines expressing significant level of HLA-G transcripts following AdC treatment. (C) 2008 Elsevier Ltd. All rights reserved

引用

页码：518 / 524

页数：7

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