Rational Design of Efficient Organic Phototherapeutic Agents via Perturbation Theory for Enhancing Anticancer Therapeutics

被引:10
|
作者
Xu, Yunjian [1 ,2 ]
Zhao, Menglong [1 ,2 ]
Wu, Licai [1 ,2 ]
Li, Feiyang [1 ,2 ]
Li, Mingdang [1 ,2 ]
Xie, Mingjuan [1 ,2 ]
Liu, Shujuan [1 ,2 ]
Huang, Wei [1 ,2 ,3 ]
Zhao, Qiang [1 ,2 ]
机构
[1] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, Inst Adv Mat, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Posts & Telecommun, Jiangsu Key Lab Biosensors, Inst Adv Mat, Nanjing 210023, Jiangsu, Peoples R China
[3] Northwestern Polytech Univ, Shaanxi Inst Flexible Elect, Xian 710072, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
aza-BODIPY; heavy atom effect; multimode imaging; perturbation theory; phototherapeutic agents; SINGLET OXYGEN GENERATION; PHOTOSENSITIZERS; NANOPARTICLES; STATES; TUMOR;
D O I
10.1002/cmdc.201900302
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The development of efficient phototherapeutic agents (PTA) through rational and specific principles exhibits great potential to the biomedical field. In this study, a facile and rational strategy was used to design PTA through perturbation theory. According to the theory, both the intersystem crossing rate for singlet oxygen generation and nonradiative transition for photothermal conversion efficiency can be simultaneously enhanced by the rational optimization of donor-acceptor groups, heavy atom number, and their functional positions, which can effectively decrease the energy gap between the singlet and triplet states and increase the spin-orbit coupling constant. Finally, efficient PTA were obtained that showed excellent performance in multimode-imaging-guided synergetic photodynamic/photothermal therapy. This study therefore expands the intrinsic mechanism of organic PTA and should help guide the rational design of future organic PTA via perturbation theory.
引用
收藏
页码:1378 / 1383
页数:6
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