Rational Design of Efficient Organic Phototherapeutic Agents via Perturbation Theory for Enhancing Anticancer Therapeutics

被引:10
|
作者
Xu, Yunjian [1 ,2 ]
Zhao, Menglong [1 ,2 ]
Wu, Licai [1 ,2 ]
Li, Feiyang [1 ,2 ]
Li, Mingdang [1 ,2 ]
Xie, Mingjuan [1 ,2 ]
Liu, Shujuan [1 ,2 ]
Huang, Wei [1 ,2 ,3 ]
Zhao, Qiang [1 ,2 ]
机构
[1] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, Inst Adv Mat, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Posts & Telecommun, Jiangsu Key Lab Biosensors, Inst Adv Mat, Nanjing 210023, Jiangsu, Peoples R China
[3] Northwestern Polytech Univ, Shaanxi Inst Flexible Elect, Xian 710072, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
aza-BODIPY; heavy atom effect; multimode imaging; perturbation theory; phototherapeutic agents; SINGLET OXYGEN GENERATION; PHOTOSENSITIZERS; NANOPARTICLES; STATES; TUMOR;
D O I
10.1002/cmdc.201900302
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The development of efficient phototherapeutic agents (PTA) through rational and specific principles exhibits great potential to the biomedical field. In this study, a facile and rational strategy was used to design PTA through perturbation theory. According to the theory, both the intersystem crossing rate for singlet oxygen generation and nonradiative transition for photothermal conversion efficiency can be simultaneously enhanced by the rational optimization of donor-acceptor groups, heavy atom number, and their functional positions, which can effectively decrease the energy gap between the singlet and triplet states and increase the spin-orbit coupling constant. Finally, efficient PTA were obtained that showed excellent performance in multimode-imaging-guided synergetic photodynamic/photothermal therapy. This study therefore expands the intrinsic mechanism of organic PTA and should help guide the rational design of future organic PTA via perturbation theory.
引用
收藏
页码:1378 / 1383
页数:6
相关论文
共 50 条
  • [1] Towards the Rational Design of Efficient Organic Structure-Directing Agents for Zeolite Synthesis
    Moliner, Manuel
    Rey, Fernando
    Corma, Avelino
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (52) : 13880 - 13889
  • [2] Enhancing the Design and Evaluation of Care Delivery for Patients on Oral Anticancer Agents
    Muluneh, Benyam
    JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2022, 20 (10): : 1185 - 1187
  • [3] Rational drug design of indazole-based diarylurea derivatives as anticancer agents
    Chu, Yan-yan
    Cheng, He-juan
    Tian, Zhen-hua
    Zhao, Jian-chun
    Li, Gang
    Chu, Yang-yang
    Sun, Chang-jun
    Li, Wen-bao
    CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 90 (04) : 609 - 617
  • [4] Rational Design of Potent and Selective EGFR Tyrosine Kinase Inhibitors as Anticancer Agents
    Ghosh, Sutapa
    Liu, Xing-Ping
    Zheng, Yaguo
    Uckun, Fatih M.
    CURRENT CANCER DRUG TARGETS, 2001, 1 (02) : 129 - 140
  • [5] Study of ruthenium(II) complexes with anticancer drugs as ligands. Design of metal-based phototherapeutic agents
    Cini, R
    Tamasi, G
    Defazio, S
    Corsini, M
    Zanello, P
    Messori, L
    Marcon, G
    Piccioli, F
    Orioli, P
    INORGANIC CHEMISTRY, 2003, 42 (24) : 8038 - 8052
  • [6] Rational design of dicarboxylato platinum(II) complexes with purinemimetic ligands as novel anticancer agents
    Hoffmann, Kamil
    Wisniewska, Joanna
    Wojtczak, Andrzej
    Sitkowski, Jerzy
    Denslow, Agnieszka
    Wietrzyk, Joanna
    Jakubowski, Mateusz
    Lakomska, Iwona
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2017, 172 : 34 - 45
  • [7] Development of pyrimidine-cinnamamide hybrids as potential anticancer agents: A rational design approach
    Ganai, Ab Majeed
    Pathan, Tabasum Khan
    Merugu, Srinivas Reddy
    Kozlanska, Karolina
    Vojackova, Veronika
    Krystof, Vladimir
    Mokoena, Sithabile
    Kayamba, Francis
    Karpoormath, Rajshekhar
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1267
  • [8] Enhancing thermostability of lysine hydroxylase via a semi-rational design
    Hu, Chengjuan
    Zheng, Zhijie
    Zhang, Yue
    Chen, Feifei
    Zhang, Alei
    Chen, Kequan
    Luo, Peicheng
    PROCESS BIOCHEMISTRY, 2025, 149 : 111 - 120
  • [9] MULTIRATE OBSERVER DESIGN VIA SINGULAR PERTURBATION-THEORY
    KANDO, H
    AOYAMA, T
    IWAZUMI, T
    INTERNATIONAL JOURNAL OF CONTROL, 1989, 50 (05) : 2005 - 2023
  • [10] Rational design of covalent organic cages via alkyne metathesis
    Moneypenny, Timothy
    Moore, Jeffrey
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254