MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis

被引：18

作者：

Baba, Toshikazu ^{[1
]}

Shinoda, Koji ^{[1
]}

Watanabe, Mitsuru ^{[1
]}

Sadashima, Shoko ^{[2
]}

Matsuse, Dai ^{[1
]}

Isobe, Noriko ^{[1
]}

Yamasaki, Ryo ^{[1
]}

Kaneko, Kimihiko ^{[3
,4
]}

Takahashi, Toshiyuki ^{[3
,5
]}

Iwaki, Toru ^{[2
]}

Kira, Jun-ichi ^{[1
]}

机构：

[1] Kyushu Univ, Neurol Inst, Grad Sch Med Sci, Dept Neurol,Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Neurol Inst, Dept Neuropathol, 3-1-1 Maidashi, Fukuoka, Fukuoka, Japan

[3] Tohoku Univ, Dept Neurol, Sch Med, Sendai, Miyagi, Japan

[4] Natl Hosp Org Miyagi Hosp, Dept Neurol, Sendai, Miyagi, Japan

[5] Natl Hosp Org Yonezawa Hosp, Dept Neurol, Yonezawa, Yamagata, Japan

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 30卷

基金：

日本学术振兴会;

关键词：

Myelin oligodendrocyte glycoprotein (MOG); Vasculitis; PCNSV; MRI; Biopsy;

D O I：

10.1016/j.msard.2019.01.053

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a 60-year-old male with anti-myelin oligodendrocyte glycoprotein (MOG) antibody who developed progressive cognitive deterioration and behavioral changes, with no other focal signs, over 9 months. MRI showed numerous T2-hyperintense lesions with partial contrast enhancement in white and grey matter of cerebrum, cerebellum and spinal cord. A brain biopsy revealed perivascular inflammatory cell infiltration, disturbed vascular continuity and no demyelination, indicative of a lymphocytic pattern of primary CNS vasculitis (PCNSV). Contrast enhancement disappeared after immunotherapy; however, cognitive impairment was not improved. Neurologists should note that MOG antibody disease can present as immunotherapy-resistant progressive cognitive impairment with PCNSV-like histopathology.

引用

页码：48 / 50

页数：3

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