MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis

被引：18

作者：

Baba, Toshikazu ^{[1
]}

Shinoda, Koji ^{[1
]}

Watanabe, Mitsuru ^{[1
]}

Sadashima, Shoko ^{[2
]}

Matsuse, Dai ^{[1
]}

Isobe, Noriko ^{[1
]}

Yamasaki, Ryo ^{[1
]}

Kaneko, Kimihiko ^{[3
,4
]}

Takahashi, Toshiyuki ^{[3
,5
]}

Iwaki, Toru ^{[2
]}

Kira, Jun-ichi ^{[1
]}

机构：

[1] Kyushu Univ, Neurol Inst, Grad Sch Med Sci, Dept Neurol,Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Neurol Inst, Dept Neuropathol, 3-1-1 Maidashi, Fukuoka, Fukuoka, Japan

[3] Tohoku Univ, Dept Neurol, Sch Med, Sendai, Miyagi, Japan

[4] Natl Hosp Org Miyagi Hosp, Dept Neurol, Sendai, Miyagi, Japan

[5] Natl Hosp Org Yonezawa Hosp, Dept Neurol, Yonezawa, Yamagata, Japan

来源：

MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2019年 / 30卷

基金：

日本学术振兴会;

关键词：

Myelin oligodendrocyte glycoprotein (MOG); Vasculitis; PCNSV; MRI; Biopsy;

D O I：

10.1016/j.msard.2019.01.053

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a 60-year-old male with anti-myelin oligodendrocyte glycoprotein (MOG) antibody who developed progressive cognitive deterioration and behavioral changes, with no other focal signs, over 9 months. MRI showed numerous T2-hyperintense lesions with partial contrast enhancement in white and grey matter of cerebrum, cerebellum and spinal cord. A brain biopsy revealed perivascular inflammatory cell infiltration, disturbed vascular continuity and no demyelination, indicative of a lymphocytic pattern of primary CNS vasculitis (PCNSV). Contrast enhancement disappeared after immunotherapy; however, cognitive impairment was not improved. Neurologists should note that MOG antibody disease can present as immunotherapy-resistant progressive cognitive impairment with PCNSV-like histopathology.

引用

页码：48 / 50

页数：3

共 50 条

[1] Rapidly progressive primary central nervous system vasculitis
Salvarani, Carlo
Brown, Robert D., Jr.
Calamia, Kenneth T.
Christianson, Teresa J. H.
Huston, John, III
Meschia, James F.
Giannini, Caterina
Miller, Dylan V.
Hunder, Gene G.
RHEUMATOLOGY, 2011, 50 (02) : 349 - 358
[2] Isolated central nervous system vasculitis manifesting as a pseudotumor
Balboa, O.
Hernandez, L.
Garcia, A. I.
Tejada, J.
RADIOLOGIA, 2006, 48 (05): : 309 - 312
[3] Primary Central Nervous System Vasculitis: Is it a Single Disease?
Hunder, Gene G.
Salvarani, Carlo
Brown, Robert D., Jr.
ANNALS OF NEUROLOGY, 2010, 68 (05) : 573 - 574
[4] Central Nervous System Vasculitis Primary Angiitis of the Central Nervous System and Central Nervous System Manifestations of Systemic Vasculitis
Amin, Moein
Uchino, Ken
Hajj-Ali, Rula A.
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2023, 49 (03) : 603 - 616
[5] Primary central nervous system vasculitis
Schuster, S.
Magnus, T.
ZEITSCHRIFT FUR RHEUMATOLOGIE, 2015, 74 (10): : 854 - +
[6] PRIMARY VASCULITIS OF THE CENTRAL NERVOUS SYSTEM
Froesehl, E.
Gallmetzer, P.
Baumgartner, C.
CEREBROVASCULAR DISEASES, 2014, 37 : 382 - 382
[7] Primary Central Nervous System Vasculitis
Salvarani, Carlo
Hunder, Gene G.
Brown, Robert D.
NEW ENGLAND JOURNAL OF MEDICINE, 2024, 391 (11): : 1028 - 1037
[8] PRIMARY CENTRAL NERVOUS SYSTEM VASCULITIS
Salvarani, C.
ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 3 - 3
[9] Primary central nervous system vasculitis and moyamoya disease: similarities and differences
Markus Kraemer
Peter Berlit
Journal of Neurology, 2010, 257 : 816 - 819
[10] Primary central nervous system vasculitis and moyamoya disease: similarities and differences
Kraemer, Markus
Berlit, Peter
JOURNAL OF NEUROLOGY, 2010, 257 (05) : 816 - 819

← 1 2 3 4 5 →