mTORC1: Turning Off Is Just as Important as Turning On

被引：20
|
作者：
Benjamin, Don [1 ]
Hall, Michael N. [1 ]
机构：
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
来源：
CELL | 2014年 / 156卷 / 04期
关键词：
RAG GTPASES;
D O I：
10.1016/j.cell.2014.01.057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
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页码：627 / 628
页数：2
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