Inhibition of amyloid fibril formation by peptide analogues modified with α-aminoisobutyric acid

被引：118

作者：

Gilead, S ^{[1
]}

Gazit, E ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 31期

关键词：

amyloid fibrils; islet amyloid polypeptide; peptides; protein folding; self assembly;

D O I：

10.1002/anie.200353565

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Breaking up is not hard to do with an α-aminoisobutyric (Aib) acid β-breaker, which has a remarkably restricted conformation. A novel approach to the inhibition of amyloid formation was developed that uses peptides modified with Aib (see figure). The similarity of Aib to hydrophobic amino acids, often found in amyloidogenic sequences, allows its integration into recognition motifs.

引用

页码：4041 / 4044

页数：4

共 50 条

[41] α2-macroglobulin associates with β-amyloid peptide and prevents fibril formation
Hughes, SR
Khorkova, O
Goyal, S
Knaeblein, J
Heroux, J
Riedel, NG
Sahasrabudhe, S
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) : 3275 - 3280
[42] A mobile precursor determines amyloid-β peptide fibril formation at interfaces
Zhu, X.-Y. (zhu@cm.utexas.edu), 1600, American Chemical Society (134):
[43] Mechanistic insights into oligomer and fibril formation of amyloid-beta peptide
Du, Deguo
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
[44] EFFECT OF ACID PREDISSOLUTION ON FIBRIL SIZE AND FIBRIL FLEXIBILITY OF SYNTHETIC BETA-AMYLOID PEPTIDE
SHEN, CL
FITZGERALD, MC
MURPHY, RM
BIOPHYSICAL JOURNAL, 1994, 67 (03) : 1238 - 1246
[45] A Mobile Precursor Determines Amyloid-β Peptide Fibril Formation at Interfaces
Shen, Lei
Adachi, Takuji
Vanden Bout, David
Zhu, X. -Y.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (34) : 14172 - 14178
[46] Inhibition of insulin amyloid fibril formation by ferulic acid, a natural compound found in many vegetables and fruits
Jayamani, Jayaraman
Shanmugam, Ganesh
Singam, Ettayapuram Ramaprasad Azhagiya
RSC ADVANCES, 2014, 4 (107) : 62326 - 62336
[47] Helical-Ribbon Formation by a β-Amino Acid Modified Amyloid β-Peptide Fragment
Castelletto, Valeria
Hamley, Ian W.
Hule, Rohan A.
Pochan, Darrin
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (13) : 2317 - 2320
[48] Molecular conformation of a peptide in an amyloid fibril
Jaroniec, CP
MacPhee, CE
Bajaj, VS
Dobson, CM
Griffin, RG
BIOPHYSICAL JOURNAL, 2003, 84 (02) : 154A - 154A
[49] Oligopeptide-mediated acceleration of amyloid fibril formation of amyloid β(Aβ) and α-synuclein fragment peptide (NAC)
Kuroda, Y
Maeda, Y
Hanaoka, H
Miyamoto, K
Nakagawa, T
JOURNAL OF PEPTIDE SCIENCE, 2004, 10 (01) : 8 - 17
[50] Inhibition of Amyloid-like Fibril Formation of Trypsin by Red Wines
Kotorman, Marta
Kasi, Phanindra B.
Halasz, Laszlo
Borics, Attila
PROTEIN AND PEPTIDE LETTERS, 2017, 24 (05): : 466 - 470

← 1 2 3 4 5 →