Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery

被引：45
|
作者：
Justin, C. [1 ]
Samrot, Antony V. [1 ]
Sruthi, Durga P. [1 ]
Sahithya, Chamarthy Sai [1 ]
Bhavya, Karanam Sai [1 ]
Saipriya, C. [1 ]
机构：
[1] Sathyabama Inst Sci & Technol, Dept Biotechnol, Chennai, Tamil Nadu, India
来源：
PLOS ONE | 2018年 / 13卷 / 07期
关键词：
ANTICANCER ACTIVITY; CHITOSAN; SPIONS; TUMOR;
D O I：
10.1371/journal.pone.0200440
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, super paramagnetic iron oxide nanoparticles (SPIONs) were produced by chemical co-precipitation method, then it was constructed to be a core shell nanoparticle by functionalizing with SDS, loading with curcumin and coating with a biopolymer i.e. chitosan. Each step was analyzed microscopically and spectroscopically. The produced coreshell particles were between 40 and 45nm and these coreshell particles were utilized for drug delivery studies against cervical cancer cell line-HeLa cells. The coreshell SPIONs were found to be releasing curcumin in between 6 and 12 h, which was evidenced by increased apoptotic cells and increased caspase 3 expression in HeLa cells.
引用
收藏
页数：18
相关论文
共 50 条
  • [31] Magnetic iron oxide nanoparticles as drug carriers: preparation, conjugation and delivery
    El-Boubbou, Kheireddine
    NANOMEDICINE, 2018, 13 (08) : 929 - 952
  • [32] Preparation and characterization of glucose-conjugated super-paramagnetic iron oxide nanoparticles (G-SPIONs) for removal of Edwardsiella tarda and Aeromonas hydrophila from water
    Kumar, Munish
    Gupta, Gyandeep
    Varghese, Tincy
    Srivastava, Prem Prakash
    Gupta, Subodh
    MICROSCOPY RESEARCH AND TECHNIQUE, 2022, 85 (05) : 1768 - 1783
  • [33] Preparation and characterization of lipid vesicles entrapping iron oxide nanoparticles
    Petralito, Stefania
    Spera, Romina
    Memoli, Adriana
    D'Inzeo, Guglielmo
    Liberti, Micaela
    Apollonio, Francesca
    ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, 2012, 7 : S335 - S341
  • [34] Preparation and characterization of iron oxide magnetic nanoparticles functionalized by nisin
    Gruskiene, Ruta
    Krivorotova, Tatjana
    Staneviciene, Ramune
    Ratautas, Dalius
    Serviene, Elena
    Sereikaite, Jolanta
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 169 : 126 - 134
  • [35] Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate
    Ma, Hui-li
    Qi, Xian-tong
    Maitani, Yoshie
    Nagai, Tsuneji
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 333 (1-2) : 177 - 186
  • [36] Functionalized chitosan with super paramagnetic hybrid nanocarrier for targeted drug delivery of curcumin
    Sriram, Kamaraj
    Maheswari, Palanisamy Uma
    Begum, Kadhar Mohamed Meera Sheriffa
    Arthanareeswaran, Gangasalam
    IRANIAN POLYMER JOURNAL, 2018, 27 (07) : 469 - 482
  • [37] Functionalized chitosan with super paramagnetic hybrid nanocarrier for targeted drug delivery of curcumin
    Kamaraj Sriram
    Palanisamy Uma Maheswari
    Kadhar Mohamed Meera Sheriffa Begum
    Gangasalam Arthanareeswaran
    Iranian Polymer Journal, 2018, 27 : 469 - 482
  • [38] Utilization of gum polysaccharide of Araucaria heterophylla and Azadirachta indica for encapsulation of cyfluthrin loaded super paramagnetic iron oxide nanoparticles for mosquito larvicidal activity
    Samrot, Antony, V
    Bhavya, Karanam Sai
    Angalene, J. Lavanya Agnes
    Roshini, S. M.
    Preethi, R.
    Steffi, S. M.
    Raji, P.
    Kumar, S. Suresh
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 153 : 1024 - 1034
  • [39] Preparation and characterization of magnetic theranostic nanoparticles for curcumin delivery and evaluation as MRI contrast agent
    Nosrati, Hamed
    Charmi, Jalil
    Abedini, Somayeh
    Rashidi, Nafis
    Attari, Elahe
    Davaran, Soodabeh
    Danafar, Hossein
    Manjili, Hamidreza Kheiri
    APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (12)
  • [40] Synthesis and characterization of controlled drug release carriers based on functionalized amphiphilic block copolymers and super-paramagnetic iron oxide nanoparticles
    Hemmati, Khadijeh
    Alizadeh, Raouf
    Ghaemy, Mousa
    POLYMERS FOR ADVANCED TECHNOLOGIES, 2016, 27 (04) : 504 - 514
12345