Preparation, characterization and utilization of coreshell super paramagnetic iron oxide nanoparticles for curcumin delivery

被引：45
|
作者：
Justin, C. [1 ]
Samrot, Antony V. [1 ]
Sruthi, Durga P. [1 ]
Sahithya, Chamarthy Sai [1 ]
Bhavya, Karanam Sai [1 ]
Saipriya, C. [1 ]
机构：
[1] Sathyabama Inst Sci & Technol, Dept Biotechnol, Chennai, Tamil Nadu, India
来源：
PLOS ONE | 2018年 / 13卷 / 07期
关键词：
ANTICANCER ACTIVITY; CHITOSAN; SPIONS; TUMOR;
D O I：
10.1371/journal.pone.0200440
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, super paramagnetic iron oxide nanoparticles (SPIONs) were produced by chemical co-precipitation method, then it was constructed to be a core shell nanoparticle by functionalizing with SDS, loading with curcumin and coating with a biopolymer i.e. chitosan. Each step was analyzed microscopically and spectroscopically. The produced coreshell particles were between 40 and 45nm and these coreshell particles were utilized for drug delivery studies against cervical cancer cell line-HeLa cells. The coreshell SPIONs were found to be releasing curcumin in between 6 and 12 h, which was evidenced by increased apoptotic cells and increased caspase 3 expression in HeLa cells.
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页数：18
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