Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2)

被引:69
|
作者
Dresser, MJ
Xiao, GQ
Leabman, MK
Gray, AT
Giacomini, KM [1 ]
机构
[1] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA
关键词
transporter; organic cation; selectivity; metformin; phenformin;
D O I
10.1023/A:1019870831174
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:1244 / 1247
页数:4
相关论文
共 50 条
  • [11] Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2
    Kimura, Naoko
    Masuda, Satohiro
    Katsura, Toshiya
    Inui, Ken-ichi
    BIOCHEMICAL PHARMACOLOGY, 2009, 77 (08) : 1429 - 1436
  • [12] Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2)
    Burger, H.
    Zoumaro-Djayoon, A.
    Boersma, A. W. M.
    Helleman, J.
    Berns, E. M. J. J.
    Mathijssen, R. H. J.
    Loos, W. J.
    Wiemer, E. A. C.
    BRITISH JOURNAL OF PHARMACOLOGY, 2010, 159 (04) : 898 - 908
  • [13] Interaction of drugs with the human organic cation transporter, hOCT2:: Influence of their molecular structure
    Solbach, T. F.
    Koenig, J.
    Fromm, M. F.
    Zolk, O.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2008, 377 : 96 - 96
  • [14] Interactions of fluoroquinolone antibacterials, DX-619 and levofloxacin, with creatinine transport by renal organic cation transporter hOCT2
    Okuda, Masahiro
    Kimura, Naoko
    Inui, Ken-Ichi
    DRUG METABOLISM AND PHARMACOKINETICS, 2006, 21 (05) : 432 - 436
  • [15] Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells
    Chiba, Shoetsu
    Ikawa, Toru
    Takeshita, Hiroshi
    Kanno, Sanae
    Nagai, Tomonori
    Takada, Meri
    Mukai, Toshiji
    Wempe, Michael F.
    TOXICOLOGY, 2013, 310 : 98 - 103
  • [16] Interaction of antihypertensives and antibiotics with hepatic (hOCT1) and renal (hOCT2) human organic cation transporters
    Ciarimboli, G
    Vollenbröker, B
    Appelo, LM
    Koepsell, H
    Schlatter, E
    FASEB JOURNAL, 2006, 20 (04): : A340 - A340
  • [17] Cysteine 474 influences the interaction of human organic cation transporter 2 (hOCT2) with TEA but not MPP
    Dangprapai, Yodying
    Pelis, Ryan M.
    Wright, Stephen H.
    FASEB JOURNAL, 2007, 21 (06): : A907 - A908
  • [18] Evidence of cysteine pairing in the long extracellular loop of human organic cation transporter 2 (hOCT2)
    Pelis, Ryan M.
    Wright, Stephen H.
    FASEB JOURNAL, 2007, 21 (06): : A908 - A908
  • [19] Molecular determinants of substrate/inhibitor binding to the human renal organic cation transport, hOCT2
    Barendt, WM
    Wright, SH
    FASEB JOURNAL, 2003, 17 (04): : A476 - A476
  • [20] Handling of β-adrenoreceptor antagonists by an epitope-tagged version of the human organic cation transporter hOCT2
    Bleasby, K
    Brown, CDA
    JOURNAL OF PHYSIOLOGY-LONDON, 2000, 527 : 28P - 29P