Prognostic significance of ARL9 and its methylation in low-grade glioma

被引：33

作者：

Tan, Yutang ^{[1
]}

Zhang, Suojun ^{[1
]}

Xiao, Qungen ^{[1
]}

Wang, Junwen ^{[1
]}

Zhao, Kai ^{[1
]}

Liu, Weihua ^{[1
]}

Huang, Kuan ^{[1
]}

Tian, Weidong ^{[1
,2
]}

Niu, Hongquan ^{[1
]}

Lei, Ting ^{[1
]}

Shu, Kai ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Neurosurg, Wuhan 430030, Peoples R China

[2] Shihezi Univ, Med Coll, Affiliated Hosp 1, Dept Neurosurg, Xinjiang 832000, Peoples R China

来源：

GENOMICS | 2020年 / 112卷 / 06期

关键词：

Low-grade glioma; ARL9; Methylation; Survival; Immune cells; GENOMIC ANALYSIS; BRAIN; SURVIVAL;

D O I：

10.1016/j.ygeno.2020.08.035

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This study aimed to determine the value of ARL9 expression or methylation as a biomarker for LGG survival. We investigated the expression, methylation, prognosis and immune significance of ARL9 through bioinformatics analysis. ARL9 is negatively regulated by ARL9 methylation, leading to its low expression in LGG tissues. Both low ARL9 expression and hypermethylation predicted favorable OS and PFS in LGG patients, according to the TCGA database. Cox regression demonstrated that low ARL9 expression and ARL9 hypermethylation were independent biomarkers for OS. Moreover, three other glioma databases were utilized to verify the prognostic role of ARL9 in LGG, and the similar results were reached. A meta-analysis revealed that low ARL9 expression was closely relevant to better OS. Finally, ARL9 expression exhibited a close correlation with some immune cells, especially CD8+ T cells. ARL9 could constitute a promising prognostic biomarker, and probably plays an important role in immune cell infiltration in LGG.

引用

页码：4808 / 4816

页数：9

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