Oxovanadium(IV) complexes of curcumin for cellular imaging and mitochondria targeted photocytotoxicity

被引：56

作者：

Banik, Bhabatosh ^{[1
]}

Somyajit, Kumar ^{[2
]}

Nagaraju, Ganesh ^{[2
]}

Chakravarty, Akhil R. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

来源：

DALTON TRANSACTIONS | 2014年 / 43卷 / 35期

关键词：

DNA CLEAVAGE; ANTICANCER ACTIVITY; BINDING; CANCER; LIGHT; CYTOTOXICITY; DEGRADATION; IRRADIATION; DELIVERY; LIGANDS;

D O I：

10.1039/c4dt01487a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Oxovanadium(IV) complexes [VO(R-tpy)(cur)](ClO4) (1, 2) of curcumin (Hcur) and terpyridine ligands (R-tpy) where R is phenyl (phtpy in 1) or p-triphenylphosphonium methylphenyl bromide (C6H4CH2PPh3Br) (TPP-phtpy in 2) were prepared and characterized and their DNA photocleavage activity, photocytotoxicity and cellular localization in cancer cells (HeLa and MCF-7) were studied. Acetylacetonate (acac) complexes [VO(R-tpy)(acac)](ClO4) of phtpy (3) and TPP-phtpy (4) were prepared and used as the control species. These complexes showed efficient cleavage of pUC19 DNA in visible light of 454 nm and near-IR light of 705 rim. Complexes 1 and 2 showed significant photocytotoxicity in visible light of 400-700 nm. FACS analysis showed sub-G1/G0 phase cell-cycle arrest in cancer cells when treated with 1 and 2 in visible light in comparison with the dark controls. Fluorescence microscopic studies revealed specific localization of the p-triphenylphosphonium complex 2 in the mitochondria of MCF-7 cancer cells whereas no such specificity was observed for complex 1.

引用

页码：13358 / 13369

页数：12

共 50 条

[21] Biotin and boron-dipyrromethene-tagged platinum(iv) prodrug for cellular imaging and mito-targeted photocytotoxicity in red light
Bera, Arpan
Nepalia, Amrita
Upadhyay, Aarti
Saini, Deepak Kumar
Chakravarty, Akhil R.
DALTON TRANSACTIONS, 2023, 52 (37) : 13339 - 13350
[22] DIMETHYLDITHIOARSINATE COMPLEXES OF OXOVANADIUM(IV)
MCCORMIC.BJ
FEATHERS.JL
WASSON, JR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1971, (NSEP): : 93 - &
[23] Oxovanadium(IV) complexes of captopril
Williams, PAM
Ferrer, EG
Baran, EJ
JOURNAL OF COORDINATION CHEMISTRY, 1997, 42 (04) : 261 - 269
[24] Oxovanadium(IV) complexes of carbohydrates
Baran, EJ
JOURNAL OF CARBOHYDRATE CHEMISTRY, 2001, 20 (09) : 769 - 788
[25] Oxovanadium(IV) Complexes of Captopril
Williams, P. A. M.
Ferrer, E. G.
Baran, E. J.
Journal of Coordination Chemistry., 42 (04):
[26] Nuclear targeting terpyridine iron(II) complexes for cellular imaging and remarkable photocytotoxicity
Basu, Uttara
Khan, Imran
Koley, Debasis
Saha, Sounik
Kondaiah, Paturu
Chakravarty, Akhil R.
JOURNAL OF INORGANIC BIOCHEMISTRY, 2012, 116 : 77 - 87
[27] Oxovanadium(IV) Silsesquioxane Complexes
Ohde, Christian
Limberg, Christian
Stoesser, Reinhard
Demeshko, Serhiy
INORGANIC CHEMISTRY, 2010, 49 (05) : 2479 - 2485
[28] BINARY AND TERNARY COMPLEXES OF OXOVANADIUM(IV) AND HOMOBINUCLEAR DOUBLE-BRIDGED OXOVANADIUM(IV) COMPLEXES
PANDYA, BJ
BHATTACHARYA, PK
TRANSITION METAL CHEMISTRY, 1987, 12 (05) : 398 - 400
[29] THE STABILITY OF OXOVANADIUM(IV)-PROPIONATE, OXOVANADIUM(IV)-BUTYRATE, AND OXOVANADIUM(IV)-ISOBUTYRATE COMPLEXES IN AQUEOUS-SOLUTION
LORENZOTTI, A
LEONESI, D
CINGOLANI, A
TUROLLA, A
GAZZETTA CHIMICA ITALIANA, 1983, 113 (3-4): : 229 - 230
[30] Models of oxovanadium(IV)-protein interactions: The first oxovanadium(IV) complexes with dipeptides
Tasiopoulos, Anastasios J.
Vlahos, Antonis T.
Keramidas, Anastasios D.
Kabanos, Themistoklis A.
Deligiannakis, Yiannis G.
Raptopoulou, Catherine P.
Terzis, Aris
Angewandte Chemie (International Edition in English), 35 (21): : 2531 - 2533

← 1 2 3 4 5 →