Autoimmune Polyglandular Syndrome Presenting with Jaundice and Thrombocytopenia

Objective: To report an uncommon presentation of a rare case of autoimmune polyglandular syndrome type IIIb in an elderly woman. Clinical Presentation and Intervention: A 62-year-old woman presented with anaemic symptoms and jaundice. Blood tests showed macrocytic anaemia due to vitamin B 12 deficiency with Coombs negative haemolysis. A thyroid function test was consistent with hypothyroidism. Autoimmune antibody assays were positive for anti-parietal cell, anti-intrinsic factor and anti-thyroid peroxidase antibodies. A final diagnosis of autoimmune thyroiditis with pernicious anaemia, which constituted autoimmune polyglandular syndrome type IIIb, was made and the patient was treated with L-thyroxine, vitamin B 12 injection and a blood transfusion. She was discharged uneventfully after a week of hospitalization. Conclusion: This case showed that the presence of one autoimmune endocrine disease should prompt clinicians to look for other coexisting autoimmune diseases which may be asymptomatic despite positive autoantibodies. (C) 2014 S. Karger AG, Basel