Angiopep-2 modi fi ed lipid-coated mesoporous silica nanoparticles for glioma targeting therapy overcoming BBB

被引：37

作者：

Zhu, Jingjing ^{[1
]}

Zhang, Ying ^{[2
]}

Chen, Xiaojie ^{[1
]}

Zhang, Yue ^{[1
]}

Zhang, Ke ^{[1
]}

Zheng, Hongyue ^{[3
]}

Wei, Yinghui ^{[1
]}

Zheng, Hangsheng ^{[1
]}

Zhu, Jiazhen ^{[1
]}

Wu, Fang ^{[4
]}

Piao, Ji-Gang ^{[1
]}

Zhu, Zhihong ^{[1
]}

Li, Fanzhu ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Peoples R China

[2] Jilin Agr Sci & Technol Univ, Coll Tradit Chinese Med, Jilin 132109, Jilin, Peoples R China

[3] Zhejiang Chinese Med Univ, Lib Zhejiang Chinese Med Univ, Hangzhou 310053, Peoples R China

[4] Zhejiang Chinese Med Univ, Radiol Dept, Affiliated Hosp 2, Hangzhou 310005, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 534卷

基金：

中国国家自然科学基金;

关键词：

Mesoporous silica nanoparticles; Lipid-coated; Angiopep-2; Intracerebral microdialysis; Glioma therapy; DRUG-DELIVERY SYSTEM; CONJUGATED NANOPARTICLES; PHASE-II; PACLITAXEL; BRAIN; RECURRENT; RELEASE;

D O I：

10.1016/j.bbrc.2020.10.076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioma is the most typical malignant brain tumor, and the chemotherapy to glioma is limited by poor permeability for crossing blood-brain-barrier (BBB) and insufficient availability. In this study, angiopep-2 modified lipid-coated mesoporous silica nanoparticle loading paclitaxel (ANG-LP-MSN-PTX) was developed to transport paclitaxel (PTX) across BBB mediated by low-density lipoprotein receptor-related protein 1 (LRP1), which is over-expressed on both BBB and glioma cells. ANG-LP-MSN-PTX was characterized with homogeneous hydrodynamic size, high drug loading capacity (11.08%) and a sustained release. In vitro experiments demonstrated that the targeting efficiency of PTX was enhanced by ANG-LPMSN-PTX with higher penetration ability (10.74%) and causing more C6 cell apoptosis. ANG-LP-MSN-PTX (20.6%) revealed higher targeting efficiency compared with LP-MSN-PTX (10.6%) via blood and intraceYYrebral microdialysis method in the pharmacokinetic study. The therapy of intracranial C6 glioma bearing rats was increasingly efficient, and ANG-LP-MSN-PTX could prolong the survival time of model rats. Taken together, ANG-LP-MSN-PTX might hold great promise as a targeting delivery system for glioma treatment. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：902 / 907

页数：6

共 42 条

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