Reactive Oxygen Species in Pathogen Clearance: The Killing Mechanisms, the Adaption Response, and the Side Effects

被引：152
|
作者：
Li, Hao [1 ]
Zhou, Xuedong [1 ]
Huang, Yuyao [1 ]
Liao, Binyou [1 ]
Cheng, Lei [1 ]
Ren, Biao [1 ]
机构：
[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2021年 / 11卷
基金：
中国国家自然科学基金;
关键词：
reactive oxygen species; secondary damage; metabolism remodeling; virulence; antibiotic resistance; antibiotic tolerance;
D O I：
10.3389/fmicb.2020.622534
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing and complexities in host environments challenge the paradigm. In the case of bacterial pathogens, the examples of some certain pathogens thriving under ROS conditions prompt us to focus on the adaption mechanism that pathogens evolve to cope with ROS. Based on these, we here summarized the mechanisms of ROS-mediated killing of either antibiotics or the host, the examples of bacterial adaption that successful pathogens evolved to defend or thrive under ROS conditions, and the potential side effects of ROS in pathogen clearance. A brief section for new antibacterial strategies centered around ROS was also addressed.
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页数：9
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