Conventional Choices in Outcome Measures Influence Meta-Analytic Results

被引：2
|
作者：
Ghomi, Hamed Tabatabaei [1 ]
Stegenga, Jacob [1 ]
机构：
[1] Univ Cambridge, Dept Hist & Philosophy Sci, Cambridge, England
来源：
PHILOSOPHY OF SCIENCE | 2022年 / 89卷 / 05期
关键词：
ABSOLUTE;
D O I：
10.1017/psa.2022.56
中图分类号：
N09 [自然科学史]; B [哲学、宗教];
学科分类号：
01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;
摘要：
It is a plausible speculation that conventional choices in outcome measures might influence the results of meta-analyses. We test that speculation by simulating data from trials on antidepressants. We vary real drug effectiveness while modulating conventional values for outcome measures. We had previously shown that one conventional choice used in meta-analyses of antidepressants falls in a narrow range of values that maximize estimates of effectiveness. Our present analysis investigates why this phenomenon occurs. Moreover, our results suggest the superiority of absolute outcome measures over relative measures. This research program can be extended to test numerous other aspects of clinical research.
引用
收藏
页码：949 / 959
页数：11
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