Neopterin is an independent prognostic variable in females with breast cancer

被引:0
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作者
Murr, C
Bergant, A
Widschwendter, M
Heim, K
Schröcksnadel, H
Fuchs, D
机构
[1] Univ Innsbruck, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria
[2] Univ Innsbruck, Dept Gynecol & Obstet, A-6020 Innsbruck, Austria
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中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Neopterin, produced by human monocytes/macrophages upon stimulation by interferon-gamma, is a sensitive marker for monitoring Th1-cell immune response in humans. In malignant diseases, the frequency of increases in neopterin in the serum and urine of patients depends on tumor stage and type. Methods: In a retrospective study comprising 129 females with breast cancer, urinary neopterin/creatinine ratios were measured at the time of diagnosis. Tumor characteristics were determined concomitantly. Results: Urinary neopterin was increased in 18% of the patients. It did not correlate with tumor size or lymph node status, but it was influenced by the presence of distant metastases (P <0.05) and by tumor differentiation (P = 0.01). When product-limit estimates were calculated after follow-up for up to 13 years (median follow-up, 56 months), the presence of distant metastases (P <0.001), neopterin (P <0.001), tumor size (P=0.001), and lymph node status (P <0.01) were Significant: predictors of survival. By multivariate analysis, a combination of the variables presence of distant metastases (P <0.001), neopterin (P <0.01), and lymph node status (P < 0.05) was found to jointly predict survival. In lymph node-negative patients without distant metastases, the relative risk of death associated with increased neopterin concentrations was 2.5 compared with patients with neopterin concentrations within the reference interval. Conclusion: Urinary neopterin provides additional prognostic information in patients with breast cancer. (C) 1999 American Association for Clinical Chemistry.
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页码:1998 / 2004
页数:7
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