Synthesis and Biological Evaluation of 5,6-Dihydro-benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer's Disease Drugs

被引：5
|
作者：
Zhou, Jinpei [2 ]
Hu, Xiaowen [1 ]
Zhang, Huibin [3 ]
Qian, Hai [3 ]
Huang, Wenlong [3 ]
Qi, Fan [2 ]
Zhang, Yanchun [2 ]
机构：
[1] Nanjing Med Univ, Dept Math & Comp, Nanjing 210029, Peoples R China
[2] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China
[3] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 08期
关键词：
Alzheimer's disease; Cholinesterase inhibitors; Neuroprotection; INHIBITORS;
D O I：
10.2174/157018009789353527
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The multifactorial pathogenesis of Alzheimer's disease (AD) suggests that drug treatments with two or more mechanisms of action, acting in a complementary manner, could be more efficacious to patients suffering from the disease. In an effort to develop new therapies to treat AD, a series of 5,6-dihydro-benzo[c] acridin-7-ol derivatives (5a-5q) were synthesized and evaluated for their AchE-inhibition and neuron-protection effects. Preliminary biological tests suggested that these compounds exhibited mild AchE-inhibition and commendable neuroprotection activities. Compounds 5m, 5n, 5p had noticeable neuron-protection as compared with tacrine and nimodipine.
引用
收藏
页码：623 / 628
页数：6
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